Conti P, Reale M, Cancelli A, Angeletti P U
Cattedra di Immunologia, Università di Chieti, Italy.
FEBS Lett. 1987 Dec 10;225(1-2):103-8. doi: 10.1016/0014-5793(87)81139-0.
Lipoxin A (LXA) is a novel eicosanoid, generated by the interactions of lipoxygenases, which has a variety of biological actions. When added to human polymorphonuclear leukocytes, LXA stimulated thromboxane formation which was monitored as TxB2 by radioimmunoassay. The compound augmented the formation of TxA2 stimulated by the ionophore of divalent cations (A23187). Formation of thromboxane was inhibited by two non-steroidal anti-inflammatory drugs (i.e. indomethacin and proglumetacin). Results of the present study indicate that LXA can provoke the release and transformation of endogenous arachidonic acid to thromboxane. Moreover, they suggest a relationship between lipoxin A and the formation of cyclooxygenase pathway products.
脂氧素A（LXA）是一种新型类二十烷酸，由脂氧合酶相互作用产生，具有多种生物学作用。当添加到人类多形核白细胞中时，LXA刺激血栓素的形成，通过放射免疫测定法将其监测为TxB2。该化合物增强了由二价阳离子离子载体（A23187）刺激的TxA2的形成。两种非甾体抗炎药（即吲哚美辛和丙谷美辛）抑制了血栓素的形成。本研究结果表明，LXA可引发内源性花生四烯酸向血栓素的释放和转化。此外，它们提示了脂氧素A与环氧化酶途径产物形成之间的关系。
