[钙离子载体（A23187）对人多形核白细胞体外血栓素B2生成的影响]
[Effect of calcium ionophore (A23187) on the production of thromboxane B2 in human polymorphonuclear cells in vitro].
作者信息
Cifone M G, El-Tawil C, El Din A S, Alesse E, Ianni G, Reale M, Continenza M A, Conti P
出版信息
Boll Soc Ital Biol Sper. 1984 Jan 30;60(1):219-25.
PMID:6422962
Abstract
Polymorphonuclear leukocytes (PMN) are capable to produce prostaglandins in vivo and in vitro, and thromboxane B2 (TXB2) which is the main metabolite of arachidonic acid in these cells. In the present work we studied, with radioimmunoassay method, the effect of calcium ionophore A23187 on PMN. This substance is capable to stimulate TXB2 release by PMN and its effect is inhibited by indomethacin.
摘要
多形核白细胞（PMN）在体内和体外均能产生前列腺素，以及血栓素B2（TXB2），后者是这些细胞中花生四烯酸的主要代谢产物。在本研究中，我们采用放射免疫分析法研究了钙离子载体A23187对PMN的影响。该物质能够刺激PMN释放TXB2，其作用可被吲哚美辛抑制。
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[Effect of calcium ionophore (A23187) on the production of thromboxane B2 in human polymorphonuclear cells in vitro].[钙离子载体（A23187）对人多形核白细胞体外血栓素B2生成的影响]
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