Bernstein Center for Computational Neuroscience Berlin, Humboldt University of Berlin, Philippstrasse 13 Haus 6, Berlin 10115, Germany.
Bernstein Center for Computational Neuroscience Berlin, Humboldt University of Berlin, Philippstrasse 13 Haus 6, Berlin 10115, Germany.
Cell Rep. 2019 Jun 18;27(12):3460-3472.e3. doi: 10.1016/j.celrep.2019.05.081.
Conspecific recognition and discrimination is a vital aspect of social interactions. Genetic manipulations have implicated the CA2 sub-field and ventral hippocampus in rodent social memory. However, little is known about the nature of hippocampal responses to social signals. We characterized ventral CA1 responses in rats while interacting with conspecifics across a gap. Many cells showed unusual "social presence responses," i.e., large elevations of firing rates, which were contingent on the presence of a conspecific. Sharp-wave ripple activity was also increased by conspecific presence. The cells were modulated by facial touch and ultrasonic vocalizations. In male rats, female conspecifics evoked stronger responses than males. In addition, responses to females differed more strongly between individual females than between males. Cells showed little response to object presence. Ventral CA1 responses were also markedly different from those of dorsal CA1, where most cells were weakly inhibited by conspecific presence.
同种识别和辨别是社交互动的一个重要方面。遗传操作表明，啮齿动物的社会记忆与 CA2 亚区和腹侧海马有关。然而，对于海马体对社交信号的反应性质知之甚少。我们在大鼠与同种个体隔着缝隙互动时，对腹侧 CA1 反应进行了描述。许多细胞表现出不寻常的“社交存在反应”，即发射率的大幅升高，这取决于同种个体的存在。尖锐波涟漪活动也因同种个体的存在而增加。细胞受到面部触摸和超声波发声的调节。在雄性大鼠中，雌性同种个体比雄性个体引起更强的反应。此外，个体雌性之间的反应差异比个体雄性之间的差异更强。细胞对物体存在的反应很小。腹侧 CA1 的反应也明显不同于背侧 CA1，背侧 CA1 的大多数细胞对同种存在有微弱的抑制作用。
Zotero 插件