CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China 100101.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China 100049.
Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16583-16592. doi: 10.1073/pnas.1819133116. Epub 2019 Jul 29.
The ability to identify strange conspecifics in societies is supported by social memory, which is vital for gregarious animals and humans. The function of hippocampal principal neurons in social memory has been extensively investigated; however, the nonprincipal neuronal mechanism underlying social memory remains unclear. Here, we first observed parallel changes in the ability for social recognition and the number of parvalbumin interneurons (PVIs) in the ventral CA1 (vCA1) after social isolation. Then, using tetanus toxin-mediated neuronal lesion and optogenetic stimulation approaches, we revealed that vCA1-PVIs specifically engaged in the retrieval stage of social memory. Finally, through the in vivo Ca imaging technique, we demonstrated that vCA1-PVIs exhibited higher activities when subjected mice approached a novel mouse than to a familiar one. These results highlight the crucial role of vCA1-PVIs for distinguishing novel conspecifics from other individuals and contribute to our understanding of the neuropathology of mental diseases with social memory deficits.
识别群居动物和人类社会中陌生同类的能力依赖于社会记忆，而社会记忆对群居动物和人类至关重要。海马主神经元在社会记忆中的功能已经得到了广泛的研究；然而，社会记忆背后的非主神经元机制仍不清楚。在这里，我们首先观察到社交隔离后社会识别能力和腹侧 CA1（vCA1）中 parvalbumin 中间神经元（PVIs）数量的平行变化。然后，使用破伤风毒素介导的神经元损伤和光遗传学刺激方法，我们揭示了 vCA1-PVIs 专门参与社会记忆的检索阶段。最后，通过在体 Ca2+成像技术，我们证明了当小鼠接近陌生小鼠时，vCA1-PVIs 表现出更高的活动水平，而当接近熟悉小鼠时则没有。这些结果突出了 vCA1-PVIs 在区分陌生同类和其他个体方面的关键作用，有助于我们理解社会记忆缺陷的精神疾病的神经病理学。
