Department of Psychology, York University, Toronto, Ontario, Canada.
Rotman Research Institute at Baycrest Hospital, Toronto, Ontario, Canada.
Hippocampus. 2024 Jun;34(6):278-283. doi: 10.1002/hipo.23604. Epub 2024 Mar 19.
Evidence suggests that individual hippocampal subfields are preferentially involved in various memory-related processes. Here, we demonstrated dissociations in these memory processes in two unique individuals with near-selective bilateral damage within the hippocampus, affecting the dentate gyrus (DG) in case BL and the cornu ammonis 1 (CA1) subfield in case BR. BL was impaired in discriminating highly similar objects in memory (i.e., mnemonic discrimination) but exhibited preserved overall recognition of studied objects, regardless of similarity. Conversely, BR demonstrated impaired general recognition. These results provide evidence for the DG in discrimination processes, likely related to underlying pattern separation computations, and the CA1 in retention/retrieval.
有证据表明，个体海马亚区优先参与各种与记忆相关的过程。在这里，我们在两个具有独特性的个体中证明了这些记忆过程的分离，他们的海马体受到了近乎选择性的双侧损伤，影响了病例 BL 的齿状回（DG）和病例 BR 的角回 1（CA1）亚区。BL 在记忆中区分高度相似的物体（即记忆辨别）方面受损，但表现出对学习物体的整体识别能力保留，而不考虑相似性。相反，BR 表现出一般识别受损。这些结果为 DG 在辨别过程中的作用提供了证据，可能与潜在的模式分离计算有关，以及 CA1 在保留/检索中的作用。
