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Platelet mechanosensing axis revealed.

作者信息

Zhang X Frank, Cheng Xuanhong

机构信息

Department of Bioengineering, Lehigh University, Bethlehem, PA, USA.

Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, USA.

出版信息

Nat Mater. 2019 Jul;18(7):661-662. doi: 10.1038/s41563-019-0393-5.

DOI:10.1038/s41563-019-0393-5
PMID:31217554
Abstract
摘要

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Platelet mechanosensing axis revealed.血小板机械传感轴被揭示。
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Flow cytometric analysis of the platelet surface area and surface density of glycoprotein IIb-IIIa of unactivated human platelets of various sizes.不同大小未激活人血小板的血小板表面积及糖蛋白IIb-IIIa表面密度的流式细胞术分析。
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A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype.糖蛋白(GP)IIIa富含半胱氨酸结构域中的一个点突变导致表达一种锁定在高亲和力状态的GPIIb-IIIa(αIIbβ3)整合素受体以及类似血小板无力症的表型。
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Effects Of Glycoprotein IIb/IIIa Antagonists: Anti Platelet Aggregation And Beyond.糖蛋白IIb/IIIa拮抗剂的作用:抗血小板聚集及其他作用
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