Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße 10, 35043, Marburg, Germany.
Curr Top Microbiol Immunol. 2020;427:35-66. doi: 10.1007/82_2019_164.
The type III secretion system (T3SS) is one of the largest transmembrane complexes in bacteria, comprising several intricately linked and embedded substructures. The assembly of this nanomachine is a hierarchical process which is regulated and controlled by internal and external cues at several critical points. Recently, it has become obvious that the assembly of the T3SS is not a unidirectional and deterministic process, but that parts of the T3SS constantly exchange or rearrange. This article aims to give an overview on the assembly and post-assembly dynamics of the T3SS, with a focus on emerging general concepts and adaptations of the general assembly pathway.
III 型分泌系统（T3SS）是细菌中最大的跨膜复合物之一，由几个复杂连接和嵌入的亚结构组成。这种纳米机器的组装是一个分层的过程，在几个关键节点受到内部和外部信号的调节和控制。最近，很明显 T3SS 的组装不是一个单向和确定性的过程，而是 T3SS 的部分不断交换或重新排列。本文旨在概述 T3SS 的组装和组装后动力学，重点介绍一般组装途径的新兴通用概念和适应性。
