Education Center for Humanities and Social Sciences, National Yang Ming University, Taipei, Taiwan.
Department of Physical Education, National Taiwan Normal University, Taipei, Taiwan.
J Appl Physiol (1985). 2019 Sep 1;127(3):798-805. doi: 10.1152/japplphysiol.01108.2018. Epub 2019 Jun 20.
The present study aims to investigate effects of caffeine ingestion and sex difference on muscle performance, delayed-onset muscle soreness (DOMS), and various biomarkers under exercise-induced muscle damage (EIMD). Twenty (10 male and 10 female) healthy elite college athletes were recruited. Participants ingested either caffeine (6 mg/kg) or a placebo in a randomized, double-blind, and counterbalanced fashion at 24 and 48 h following EIMD. Muscle performance, DOMS, and blood samples were taken an hour before and an hour after supplementation. Caffeine ingestion restored impaired maximal voluntary isometric contractions (MVIC: 10.2%; MVIC: 7.2%, both < 0.05) during EIMD across both sexes. Following caffeine ingestion during MVIC, while affected by EIMD, an interaction was found in DOMS and serum K (both < 0.05), with males showing greater attenuation (21.5 and 16.9%, respectively) compared with females (4.6 and 1.3%, respectively). DOMS demonstrated an inverse correlation with MVIC after caffeine ingestion both overall and among male athletes ( -0.34 and -0.54, respectively; < 0.05) but not among female athletes ( -0.11; > 0.05) under EIMD. In addition, caffeine ingestion increased postexercise serum glucose and lactate concentrations across both sexes (both < 0.05). This is the first study to show that male athletes, compared with female athletes, experience a greater reduction in DOMS during enhanced MVIC when caffeine was consumed, suggesting men might receive greater ergogenic effects from caffeine when affected by EIMD. Furthermore, caffeine ingestion was able to restore impaired muscle power among elite collegiate athletes across both sexes. Exercise-induced muscle damage (EIMD) reduces anaerobic/aerobic performance and increases delayed-onset muscle soreness (DOMS) during exercise. We show that acute caffeine supplementation at a dosage of 6 mg/kg seems to facilitate recovery of anaerobic muscle power and attenuate DOMS after EIMD across both sexes. Furthermore, male athletes, compared with female athletes, when caffeine was prescribed, experience a greater reduction in DOMS with better restoration of impaired maximal voluntary isometric contractions. This suggests that male athletes might benefit from the ergogenic effect of acute caffeine supplementation after the onset of EIMD.
本研究旨在探讨咖啡因摄入和性别差异对运动引起的肌肉损伤（EIMD）下肌肉性能、延迟性肌肉酸痛（DOMS）和各种生物标志物的影响。招募了 20 名（10 名男性和 10 名女性）健康的精英大学生运动员。参与者在 EIMD 后 24 小时和 48 小时以随机、双盲和对照的方式摄入咖啡因（6mg/kg）或安慰剂。在补充前后一小时内采集肌肉性能、DOMS 和血液样本。咖啡因摄入恢复了男女两性 EIMD 期间受损的最大自主等长收缩（MVIC：10.2%；MVIC：7.2%，均 < 0.05）。在摄入咖啡因后进行 MVIC 时，尽管受到 EIMD 的影响，但 DOMS 和血清 K 之间存在相互作用（均 < 0.05），男性的衰减幅度（分别为 21.5%和 16.9%）大于女性（分别为 4.6%和 1.3%）。在摄入咖啡因后，DOMS 与 MVIC 呈负相关，无论是整体还是男性运动员（分别为 -0.34 和 -0.54，均 < 0.05），但女性运动员（ -0.11；> 0.05）则没有。此外，咖啡因摄入增加了男女两性运动后的血清葡萄糖和乳酸浓度（均 < 0.05）。这是第一项表明男性运动员在摄入咖啡因时，与女性运动员相比，在增强的 MVIC 中经历的 DOMS 减少更大的研究，表明男性在受到 EIMD 影响时可能会从咖啡因中获得更大的运动表现增强效果。此外，咖啡因摄入能够恢复男女两性精英大学生运动员受损的肌肉力量。运动引起的肌肉损伤（EIMD）会降低无氧/有氧性能并增加运动时的延迟性肌肉酸痛（DOMS）。我们表明，6mg/kg 的急性咖啡因补充似乎有助于在男女两性中恢复无氧肌肉力量并减轻 EIMD 后的 DOMS。此外，与女性运动员相比，当给男性运动员服用咖啡因时，DOMS 减少幅度更大，受损的最大自主等长收缩恢复更好。这表明男性运动员可能会从 EIMD 发作后急性咖啡因补充的运动表现增强效果中受益。
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