1US Transuranium and Uranium Registries, Washington State University.
US Transuranium and Uranium Registries, Washington State University.
Health Phys. 2019 Aug;117(2):202-210. doi: 10.1097/HP.0000000000001123.
The skeleton is one of the major retention sites for internally deposited actinides. Thus, an accurate estimation of the total skeleton content of these elements is important for biokinetic modeling and internal radiation dose assessment. Data from 18 whole-body donations to the US Transuranium and Uranium Registries with known plutonium intakes were used to develop a simple and reliable method for estimation of plutonium and Am activity in the total skeleton from single-bone analysis. A coefficient of deposition Kdep, defined as the ratio of actinide content in the patella to that in the skeleton, was calculated for Pu, Pu, and Am. No statistical difference was found in Kdep values among these radionuclides. Variability in Kdep values was investigated with relation to skeleton pathology (osteoporosis). The average Kdep of 0.0051 ± 0.0009 for the osteoporotic group was statistically different from Kdep of 0.0032 ± 0.0010 for nonosteoporotic individuals. The use of Kdep allows for rapid estimation of the total skeletal content of plutonium and Am with up to 35% uncertainty. To improve accuracy and precision of total skeleton activity estimates, regression analysis with power function was applied to the data. Strong correlation (r > 0.9) was found between Pu, Pu, and Am activities measured in the patella bone and total skeleton activity. The results of this study are specifically important for the optimization of bone sample collection for US Transuranium and Uranium Registries partial-body donations.
骨骼是内照射锕系元素的主要蓄积部位之一。因此，准确估计这些元素在整个骨骼中的总量对于生物动力学建模和内部辐射剂量评估非常重要。利用美国超铀元素和铀登记处已知钚摄入量的 18 例全身捐献者的数据，开发了一种简单可靠的方法，可从单骨分析中估算骨骼中总钚和镅的活度。定义沉积系数 Kdep 为髌骨中锕系元素含量与骨骼中锕系元素含量的比值，用于 Pu、Pu 和 Am。这些放射性核素的 Kdep 值没有统计学差异。还研究了 Kdep 值的变化与骨骼病理（骨质疏松症）的关系。骨质疏松组的平均 Kdep 值为 0.0051 ± 0.0009，与非骨质疏松个体的 0.0032 ± 0.0010 有统计学差异。使用 Kdep 可以在 35%不确定度内快速估算骨骼中钚和镅的总量。为了提高骨骼总量活度估算的准确性和精密度，对数据进行了幂函数回归分析。在髌骨骨和总骨骼活性中发现 Pu、Pu 和 Am 活性之间存在很强的相关性（r>0.9）。本研究的结果对于优化美国超铀元素和铀登记处部分身体捐献的骨骼样本采集特别重要。
