Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Instituto de Nutrição Josué de Castro, Av. Carlos Chagas Filho, 373 - bloco J, Cidade Universitária, Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Instituto de Nutrição Josué de Castro, Av. Carlos Chagas Filho, 373 - bloco J, Cidade Universitária, Rio de Janeiro, RJ, Brazil.
Diabetes Res Clin Pract. 2019 Aug;154:9-16. doi: 10.1016/j.diabres.2019.06.005. Epub 2019 Jun 17.
To assess predictors of non-HDL cholesterol in children and adolescents with T1DM.
A cross-sectional study of 120 children and adolescents aged 7-16 with T1DM, but without any other chronic morbidities, at a referral outpatient clinic for the treatment of diabetes in Rio de Janeiro, Brazil. Socio-demographic, anthropometric, dietary, and clinical factors were assessed, which included measurements of serum lipids and glycated hemoglobin (HbA1c). Food intake was assessed by 24-h dietary recall. Multiple linear regression was adopted in the analysis.
The mean age of of the subjects was 11.74 ± 2.88 years, 53.3% were female, and the mean duration of T1DM was 6.68 ± 3.33 years. The mean energy intake from carbohydrates, proteins, and lipids was 51.98% (±9.20), 21.43% (±6.13), and 26.57% (±9.98), respectively. The energy intake from processed and ultra-processed foods represented 40.79% of total energy intake. The predictors of non-HDL cholesterol were: HbA1c (%) (p = 0.000, β = 8.5, CI: 4.8-12.1), duration of T1DM (p = 0.000, β = 2.8, CI: 1.3-4.3), and sex (p = 0.032, β = 10.1, CI: 0.9-19.4).
Glycemic control was the major modifiable predictor of non-HDL cholesterol concentrations, a significant indicator of cardiovascular risk.
评估 T1DM 患儿和青少年非高密度脂蛋白胆固醇的预测因素。
这是一项在巴西里约热内卢的糖尿病治疗转诊门诊对 120 名年龄在 7-16 岁的 T1DM 但无其他慢性合并症的儿童和青少年进行的横断面研究。评估了社会人口统计学、人体测量学、饮食和临床因素，包括血清脂质和糖化血红蛋白（HbA1c）的测量。通过 24 小时膳食回忆评估食物摄入量。采用多元线性回归进行分析。
受试者的平均年龄为 11.74±2.88 岁，53.3%为女性，T1DM 的平均病程为 6.68±3.33 年。碳水化合物、蛋白质和脂肪的平均能量摄入量分别为 51.98%（±9.20）、21.43%（±6.13）和 26.57%（±9.98）。加工和超加工食品的能量摄入量占总能量摄入量的 40.79%。非高密度脂蛋白胆固醇的预测因素为：HbA1c（%）（p=0.000，β=8.5，CI：4.8-12.1）、T1DM 病程（p=0.000，β=2.8，CI：1.3-4.3）和性别（p=0.032，β=10.1，CI：0.9-19.4）。
血糖控制是非高密度脂蛋白胆固醇浓度的主要可调节预测因素，是心血管风险的重要指标。
