Neural Developmental Biology Lab, Department of Life Science, National Institute of Technology , Rourkela , India.
Toxicol Mech Methods. 2019 Oct;29(8):549-560. doi: 10.1080/15376516.2019.1634171. Epub 2019 Jul 19.
Diabetes and obesity are the two notorious metabolic disorders in today's world. Both diabetes and obesity are interlinked with each other and often referred to as 'Diabesity'. It is a complex and multi-organ failure disorder. Thus, many researches and tremendous efforts have been made toward prevention, treatment as well as early detection of diabesity. However, and still, there is a large gap in understanding the etiology as well as treatment of diabesity. Various animal models are also used to decipher the mechanism underlying diabesity. Among all the model organism, recently is gaining its importance to study diabetes, obesity, and other metabolic disorder. Various experimental methods like histological, biochemical, developmental, and behavioral assays are described in this study to detect diabetes as well as obesity in the fly model.
糖尿病和肥胖症是当今世界两种臭名昭著的代谢紊乱疾病。糖尿病和肥胖症相互关联，通常被称为“糖尿病肥胖症”。它是一种复杂的多器官衰竭疾病。因此，已经进行了许多研究，并付出了巨大的努力来预防、治疗和早期发现糖尿病肥胖症。然而，人们对糖尿病肥胖症的病因和治疗仍存在很大的认识差距。各种动物模型也被用于破解糖尿病肥胖症的发病机制。在所有的模式生物中，最近 模型在研究糖尿病、肥胖症和其他代谢紊乱方面的重要性日益增加。本研究描述了各种实验方法，如组织学、生化、发育和行为分析，以检测果蝇模型中的糖尿病和肥胖症。
