哥伦比亚媒介和动物储存宿主中克氏锥虫感染率的异质性：系统评价和荟萃分析。

Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis.

机构信息

Facultad de Medicina, Universidad El Bosque, Bogotá, Colombia.

Grupo de Investigación en Enfermedades Tropicales del Ejercito (GINETEJ), Bogotá, Colombia.

出版信息

Parasit Vectors. 2019 Jun 20;12(1):308. doi: 10.1186/s13071-019-3541-5.

DOI:10.1186/s13071-019-3541-5

PMID:31221188

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6585012/

Abstract

BACKGROUND

The heterogeneity of Trypanosoma cruzi infection rates among triatomines insects and animal reservoirs has been studied in independent studies, but little information has been systematised to allow pooled and comparative estimates. Unravelling the main patterns of this heterogeneity could contribute to a further understanding of T. cruzi transmission in Colombia.

METHODS

A systematic search was conducted in PubMed, Medline, LILACS, Embase, Web of Knowledge, Google Scholar and secondary sources with no filters of language or time and until April 2018. Based on selection criteria, all relevant studies reporting T. cruzi infection rates in reservoirs or triatomines were chosen. For pooled analyses, a random effects model for binomial distribution was used. Heterogeneity among studies is reported as I. Subgroup analyses included: taxonomic classification, ecotope and diagnostic methods. Publication bias and sensitivity analyses were performed.

RESULTS

Overall, 39 studies reporting infection rates in Colombia were found (22 for potential reservoirs and 28 for triatomine insects) for a total sample of 22,838 potential animals and 11,307 triatomines evaluated for T. cruzi infection. We have found evidence of 38/71 different animal species as potential T. cruzi reservoirs and 14/18 species as triatomine vectors for T. cruzi. Among animals, the species with the highest pooled prevalence were opossum (Didelphis marsupialis) with 48.0% (95% CI: 26-71%; I = 88%, τ = 0.07, P < 0.01) and domestic dog (Canis lupus familiaris) with 22.0% (95% CI: 4-48%; I = 96%, τ = 0.01, P < 0.01). Among triatomines, the highest prevalence was found for Triatoma maculata in the peridomestic ecotope (68.0%, 95% CI: 62-74%; I = 0%, τ = 0, P < 0.0001), followed by Rhodnius prolixus (62.0%, 95% CI: 38-84%; I = 95%, τ = 0.05, P < 0.01) and Rhodnius pallescens (54.0%, 95% CI: 37-71%; I = 86%, τ = 0.035, P < 0.01) in the sylvatic ecotope.

CONCLUSIONS

To our knowledge, this is the first systematic and quantitative analyses of triatomine insects and potential animal reservoirs for T. cruzi infection in Colombia. The results highlight a marked heterogeneity between species and provide initial estimates of infection rates heterogeneity.

摘要

背景

在独立的研究中已经研究了克氏锥虫感染率在白蛉和动物宿主中的异质性，但很少有信息被系统化以允许进行汇总和比较估计。揭示这种异质性的主要模式可能有助于进一步了解哥伦比亚的克氏锥虫传播。

方法

在 PubMed、Medline、LILACS、Embase、Web of Knowledge、Google Scholar 和二级来源中进行了系统搜索，没有语言或时间过滤器，直到 2018 年 4 月。根据选择标准，选择了所有报告哥伦比亚储主或白蛉中克氏锥虫感染率的相关研究。对于汇总分析，使用二项分布的随机效应模型。研究之间的异质性用 I 表示。亚组分析包括：分类学分类、生态位和诊断方法。进行了发表偏倚和敏感性分析。

结果

总体而言，发现了 39 项报告哥伦比亚感染率的研究（22 项针对潜在储主，28 项针对白蛉昆虫），总共对 22838 种潜在动物和 11307 只白蛉进行了克氏锥虫感染评估。我们已经发现 71 种不同动物物种中有 38 种是潜在的克氏锥虫储主，18 种是克氏锥虫的白蛉传播媒介。在动物中，具有最高汇总患病率的物种是负鼠（Didelphis marsupialis），患病率为 48.0%（95%CI：26-71%；I=88%，τ=0.07，P<0.01），家养狗（Canis lupus familiaris）为 22.0%（95%CI：4-48%；I=96%，τ=0.01，P<0.01）。在白蛉中，最高的患病率是在半家栖生态位的 Triatoma maculata，为 68.0%（95%CI：62-74%；I=0%，τ=0，P<0.0001），其次是 Rhodnius prolixus（62.0%，95%CI：38-84%；I=95%，τ=0.05，P<0.01）和 Rhodnius pallescens（54.0%，95%CI：37-71%；I=86%，τ=0.035，P<0.01）在森林生态位。