Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran.
Mol Divers. 2020 Aug;24(3):841-853. doi: 10.1007/s11030-019-09972-1. Epub 2019 Jun 20.
Ugi-azide four-component reaction (UA-4CR) as development on Ugi four-component reaction (U-4CR) is the condensation reaction involving an aldehyde, an amine, an isocyanide, and an azide source. Nowadays, UA-4CR has been employed for the efficient and facile production of 1,5-disubstituted-1H-tetrazoles (1,5-DS-1H-Ts). Interestingly, the combination of 1,5-DS-1H-Ts with suitable post-transformations in a tandem manner results in the construction of various classes of heterocyclic compounds bearing 1,5-DS-1H-T moiety. This review aims to provide the application of diverse post-Ugi-azide reaction in the preparation of different N-heterocyclic compounds bearing 1,5-DS-1H-T such as substituted and fused 1,5-DS-1H-Ts.
Ugi-叠氮四组分反应（UA-4CR）是 Ugi 四组分反应（U-4CR）的发展，它是一种涉及醛、胺、异氰化物和叠氮源的缩合反应。如今，UA-4CR 已被用于高效、简便地合成 1,5-二取代-1H-四唑（1,5-DS-1H-Ts）。有趣的是，1,5-DS-1H-Ts 与合适的后转化反应以串联方式结合，导致构建了各种含有 1,5-DS-1H-T 部分的杂环化合物。这篇综述旨在提供不同的后 Ugi-叠氮反应在制备含有 1,5-DS-1H-T 的不同 N-杂环化合物中的应用，如取代和稠合的 1,5-DS-1H-Ts。
