Haslam C, Stevens R, Donohoe T P
Department of Psychology, University of Nottingham, UK.
Psychopharmacology (Berl). 1987;93(2):201-6. doi: 10.1007/BF00179934.
Repeated bodily immobilization significantly reduced the food intake of ovariectomized rats. Additionally, immobilization and oestradiol benzoate were found to produce additive effects in depressing feeding. To determine whether serotonergic mechanisms are involved in the stress- and oestrogen-induced anorexia, the 5-HT antagonist cyproheptadine was given to ovariectomized rats that were immobilized and treated with oestradiol benzoate. Cyproheptadine had no effect on the anorexia produced by oestradiol. The food intake of immobilized rats treated with cyproheptadine was similar to control values, suggesting 5-HT involvement in the stress-induced anorexia. However, cyproheptadine had no ameliorating effects on the changes in body weight following immobilization treatment. The implications of these findings are discussed in relation to a possible neuroendocrine basis for anorexia.
反复的身体固定显著降低了去卵巢大鼠的食物摄入量。此外，发现固定和苯甲酸雌二醇在抑制进食方面产生相加作用。为了确定血清素能机制是否参与应激和雌激素诱导的厌食症，将5-羟色胺拮抗剂赛庚啶给予接受固定并经苯甲酸雌二醇处理的去卵巢大鼠。赛庚啶对苯甲酸雌二醇引起的厌食症没有影响。用赛庚啶处理的固定大鼠的食物摄入量与对照值相似，表明5-羟色胺参与应激诱导的厌食症。然而，赛庚啶对固定处理后体重的变化没有改善作用。结合厌食症可能的神经内分泌基础对这些发现的意义进行了讨论。
