Donohoe T P, Kennett G A, Curzon G
Life Sci. 1987 Feb 2;40(5):467-72. doi: 10.1016/0024-3205(87)90112-3.
The relationship between the anorexia following immobilisation and the associated gastric pathology in male and female rats was investigated. Male rats were injected with saline or the histamine-H2. antagonist, ranitidine, which inhibits gastric acid secretion but does not readily enter the brain. Thirty minutes later, the animals were immobilised for 2 hours. Ranitidine pretreatment reduced the number of gastric lesions but had no effect on the degree of stress-induced anorexia. The number of gastric lesions did not correlate significantly with the degree of anorexia or weight loss. Previous studies have reported that female rats (unlike males) exhibit anorexia after repeated daily immobilisations and have greater gastric pathology following stress. Therefore, in a second experiment, female rats were pretreated with saline or ranitidine and immobilised for 2 hours/day for 4 days. The drug did not decrease the number of lesions observed after this treatment. However, as in the first experiment, the number of lesions did not correlate significantly with anorexia or weight loss. It is therefore unlikely that immobilisation stress-induced anorexia in either male or female rats is merely a consequence of gastric ulceration.
研究了雄性和雌性大鼠制动后厌食与相关胃部病理之间的关系。给雄性大鼠注射生理盐水或组胺H2拮抗剂雷尼替丁，雷尼替丁可抑制胃酸分泌，但不易进入大脑。30分钟后，将动物制动2小时。雷尼替丁预处理减少了胃部病变的数量，但对应激诱导的厌食程度没有影响。胃部病变的数量与厌食程度或体重减轻没有显著相关性。先前的研究报道，雌性大鼠（与雄性不同）在每日重复制动后会出现厌食，且应激后有更严重的胃部病理变化。因此，在第二个实验中，给雌性大鼠用生理盐水或雷尼替丁预处理，并每天制动2小时，持续4天。该药物并没有减少这种处理后观察到的病变数量。然而，与第一个实验一样，病变数量与厌食或体重减轻没有显著相关性。因此，无论是雄性还是雌性大鼠，制动应激诱导的厌食不太可能仅仅是胃溃疡的结果。
