Berglund Scherwitzl Elina, Lundberg Olof, Kopp Kallner Helena, Rowland Simon P, Holte Jan, Trussell James, Gemzell Danielsson Kristina, Scherwitzl Raoul
a NaturalCycles Nordic AB , Stockholm , Sweden.
b Department of Clinical Sciences at Danderyd Hospital , Karolinska Institutet , Stockholm , Sweden.
Eur J Contracept Reprod Health Care. 2019 Aug;24(4):260-265. doi: 10.1080/13625187.2019.1621999. Epub 2019 Jun 21.
The aim of the study was to compare the effect of previously used contraceptive methods on women's short- and long-term fecundity. Use of hormonal contraception (HC) was compared with the use of a contraceptive mobile application (app). This real-life prospective observational study comprised 2874 women who were attempting to become pregnant using the Natural Cycles mobile app to monitor their fertility. The women registered to use the app between August 2014 and June 2016 with the intention of planning a pregnancy and had previously either used the same app to prevent pregnancy or had recently discontinued HC use. We calculated the average time to pregnancy (TTP) for all women who became pregnant during the study and performed Kaplan-Meier life-table analysis to examine the cumulative probabilities of pregnancy for all women in the study. The average TTP was 2.3 (95% confidence interval [CI] 2.1, 2.4) and 3.7 (95% CI 3.4, 3.9) cycles for women who had previously used Natural Cycles and HC, respectively. The time to reach 30% pregnancy probability for women previously on HC was 1.6 (95% CI 1.5, 1.8) times longer than for women previously using Natural Cycles. There was no significant difference in the 13 cycle cumulated pregnancy probability between the two groups. The results show that fertility awareness-based methods of contraception increase short-term pregnancy rates relative to HC, but have no effect on long-term pregnancy rates.
该研究的目的是比较先前使用的避孕方法对女性短期和长期生育能力的影响。将激素避孕（HC）的使用与避孕移动应用程序（应用程序）的使用进行了比较。这项现实生活中的前瞻性观察性研究包括2874名试图使用自然周期移动应用程序监测其生育能力以怀孕的女性。这些女性在2014年8月至2016年6月期间注册使用该应用程序，目的是计划怀孕，并且之前要么使用同一应用程序避孕，要么最近停止使用HC。我们计算了研究期间所有怀孕女性的平均怀孕时间（TTP），并进行了Kaplan-Meier生命表分析，以检查研究中所有女性的累积怀孕概率。先前使用自然周期和HC的女性的平均TTP分别为2.3（95%置信区间[CI]2.1，2.4）和3.7（95%CI 3.4，3.9）个周期。先前使用HC的女性达到30%怀孕概率的时间比先前使用自然周期的女性长1.6（95%CI 1.5，1.8）倍。两组之间的13个周期累积怀孕概率没有显著差异。结果表明，相对于HC，基于生育意识的避孕方法可提高短期怀孕率，但对长期怀孕率没有影响。
