高迁移率族蛋白 B1：一种免疫调节蛋白。
High Mobility Group Box 1: An Immune-regulatory Protein.
机构信息
Department of Intensive Care Medicine, Hefei No. 2 People Hospital, Hefei 230000, China.
Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215000, China.
出版信息
Curr Gene Ther. 2019;19(2):100-109. doi: 10.2174/1566523219666190621111604.
High mobility group box 1 (HMGB1) presents in almost all somatic cells as a component of the cell nucleus. It is necessary for transcription regulation during cell development. Recent studies indicate that extracellular HMGB1, coming from necrotic cells or activated immune cells, triggers inflammatory response whereas intracellular HMGB1 controls the balance between autophagy and apoptosis. In addition, reduced HMGB1 can effectively mediate tissue regeneration. HMGB1, therefore, is regarded as a therapeutic target for inflammatory diseases. In this review, we summarized and discussed the immunomodulatory effect of HMGB1.
高迁移率族蛋白 B1（HMGB1）几乎存在于所有体细胞的细胞核中，是细胞发育过程中转录调控所必需的。最近的研究表明，来自坏死细胞或激活的免疫细胞的细胞外 HMGB1 会引发炎症反应，而细胞内 HMGB1 则控制自噬和凋亡之间的平衡。此外，HMGB1 的减少可以有效地介导组织再生。因此，HMGB1 被认为是炎症性疾病的治疗靶点。在这篇综述中，我们总结和讨论了 HMGB1 的免疫调节作用。
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