Comprehensive Analysis Revealed that is a Biomarker for Immune Infiltrates in Multiple Cancers.

The (cyclin dependent kinase inhibitor 2A/multiple tumor suppressor 1) gene, also known as the gene, encodes multiple tumor suppressor 1 (), which belongs to the INK4 family. In tumor tissue, has a high expression level compared with normal tissue and reflects prognosis in tumor patients. Our research targeted the analysis of expression in 33 tumors and clinical parameters, patient prognosis and tumor immunity roles. The expression level was significantly correlated with the tumor mutation burden (TMB) in 10 tumors, and the expression of was also correlated with MSI (microsatellite instability) in 10 tumors. expression was associated with infiltrating lymphocyte (TIL) levels in 22 pancancers, thus suggesting that expression is associated with tumor immunity. Enrichment analysis indicated that expression was involved in natural killer cell-mediated cytotoxicity pathways, antigen processing and presentation, olfactory transduction pathways, and regulation of the autophagy pathway in multiple cancers. was significantly associated with several immune cell infiltrates in pantumors. may serve as a promising prognostic biomarker and is associated with immune infiltrates across cancers.