Elmezughi Khaled, Ekpebegh Chukwuma
Department of Internal Medicine, Walter Sisulu University, Mthatha, South Africa.
Pan Afr Med J. 2019 Mar 11;32:112. doi: 10.11604/pamj.2019.32.112.18271. eCollection 2019.
Metformin is a commonly used treatment modality in type 2 diabetes mellitus with lactic acidosis as a rare but life-threatening side effect. In this case report we highlight the importance of recognizing this uncommon side effect and the treatment options in a resource limited situation. We present a 14-year-old African girl who ingested an unknown amount of metformin intentionally after an argument with her mother. She was referred late to our institution in severe lactic acidosis. Lactic acidosis resolved with appropriate treatment including peritoneal dialysis. We conclude that in resource constrained settings, peritoneal dialysis may be used for metformin associated lactic acidosis with favourable outcome.
二甲双胍是2型糖尿病常用的治疗药物，乳酸酸中毒是其罕见但危及生命的副作用。在本病例报告中，我们强调了在资源有限的情况下识别这种罕见副作用及其治疗方案的重要性。我们报告了一名14岁非洲女孩，在与母亲争吵后故意服用了未知剂量的二甲双胍。她因严重乳酸酸中毒被转诊至我院时已延误。通过包括腹膜透析在内的适当治疗，乳酸酸中毒得到缓解。我们得出结论，在资源有限的情况下，腹膜透析可用于治疗二甲双胍相关的乳酸酸中毒，且效果良好。
