Müller A, Bernstein H G, Wiederanders B, Röse I, Dorn A
Institute of Anatomy, Medical Academy Magdeburg, GDR.
Acta Histochem. 1987;82(1):29-33. doi: 10.1016/S0065-1281(87)80046-6.
An antiserum against rat liver cathepsin D, which was previously found to cross-react with human brain cathepsin(s) D, was used to immunolocalize the enzyme in developing CNS man. Cathepsin D protein was found in neurons as well as in glial cells. The aerliest occurrence of cathepsin D was observed in neuroblasts at the 12th gestational week. During pre-, peri-, and postnatal neuroontogenesis, there is a strong increase in the amount of immunoreactive material.
一种抗大鼠肝脏组织蛋白酶D的抗血清，先前发现它可与人脑组织蛋白酶D发生交叉反应，被用于在发育中的人类中枢神经系统中对该酶进行免疫定位。在神经元以及神经胶质细胞中均发现了组织蛋白酶D蛋白。在妊娠第12周时，在成神经细胞中观察到组织蛋白酶D最早出现。在产前、围产期和产后的神经发生过程中，免疫反应性物质的量有显著增加。
