Dorn A, Müller A, Kirschke H, Wiederanders B, Bernstein H G
Biomed Biochim Acta. 1986;45(11-12):1457-60.
The aspartic endopeptidase cathepsin D was demonstrated in post mortem human brain by means of the peroxidase-antiperoxidase technique. The enzyme protein was found to be present in multiple neurons as well as in some glial cells. In embryonic nervous tissue cathepsin D was detected as early as at the 12th gestational week. During neuroontogenesis there was a continuous increase in cathepsin D immunoreactivity.
通过过氧化物酶-抗过氧化物酶技术在人死后的大脑中证实了天冬氨酸内肽酶组织蛋白酶D。发现该酶蛋白存在于多个神经元以及一些神经胶质细胞中。在胚胎神经组织中，早在妊娠第12周就检测到了组织蛋白酶D。在神经发生过程中，组织蛋白酶D的免疫反应性持续增加。
