Pacheu-Grau David, Rucktäschel Robert, Deckers Markus
Department of Cellular Biochemistry, University Medical Center Göttingen, Germany.
Cell Stress. 2018 Jul 13;2(8):184-199. doi: 10.15698/cst2018.07.147.
Mitochondrial bioenergetics require the coordination of two different and independent genomes. Mutations in either genome will affect mitochondrial functionality and produce different sources of cellular stress. Depending on the kind of defect and stress, different tissues and organs will be affected, leading to diverse pathological conditions. There is no curative therapy for mitochondrial diseases, nevertheless, there are strategies described that fight the various stress forms caused by the malfunctioning organelles. Here, we will revise the main kinds of stress generated by mutations in mitochondrial genes and outline several ways of fighting this stress.
线粒体生物能量学需要两个不同且独立的基因组协同作用。任一基因组发生突变都会影响线粒体功能，并产生不同的细胞应激源。根据缺陷和应激的类型，不同的组织和器官会受到影响，从而导致多种病理状况。线粒体疾病尚无治愈疗法，不过，已有一些策略可对抗由功能异常的细胞器引发的各种应激形式。在此，我们将审视线粒体基因突变产生的主要应激类型，并概述几种对抗这种应激的方法。
