Cockcroft D W
Department of Medicine, University Hospital, Saskatoon, Saskatchewan, Canada.
Ann Allergy. 1987 Dec;59(6):405-14.
In summary, this article has reviewed the importance of airway inflammation in the pathogenesis of asthma. Inflammatory triggering factors (allergen, low molecular weight sensitizing chemicals, viral URTI) are more important in the pathogenesis of asthma than the bronchospastic triggering factors. Likewise, anti-inflammatory treatment strategies (environmental control, sodium cromoglycate, steroids) are more important in the long-term control of asthma than are the purely bronchodilator strategies.
总之,本文回顾了气道炎症在哮喘发病机制中的重要性。炎症触发因素(变应原、低分子量致敏化学物质、病毒性上呼吸道感染)在哮喘发病机制中比支气管痉挛触发因素更为重要。同样,抗炎治疗策略(环境控制、色甘酸钠、类固醇)在哮喘的长期控制中比单纯的支气管扩张剂策略更为重要。