Cockcroft D W
Can Fam Physician. 1989 Jul;35:1503-7.
Asthma, seen primarily as an inflammatory disease with secondary airway hyper-responsiveness, causes symptoms through contraction of the airway's smooth muscles. The management of chronic asthma relies on bronchodilators for symptomatic relief of bronchospasm, while primary therapy is used to either prevent or reverse the inflammatory component of the disease. Anti-inflammatory therapeutic strategies include environmental control (where relevant), sodium cromoglycate (where appropriate), and both inhaled and oral glucocorticosteroids. Management of acute severe asthma is similar; bronchodilators are used to "buy time" while systemic corticosteroids control the inflammatory process.
哮喘主要被视为一种伴有继发性气道高反应性的炎症性疾病,通过气道平滑肌收缩引发症状。慢性哮喘的治疗依赖支气管扩张剂缓解支气管痉挛症状,而主要治疗则用于预防或逆转疾病的炎症成分。抗炎治疗策略包括(如适用)环境控制、色甘酸钠(如合适)以及吸入和口服糖皮质激素。急性重症哮喘的治疗类似;支气管扩张剂用于“争取时间”,而全身性皮质类固醇控制炎症过程。