Cockcroft D W
Section of Respiratory Medicine, University Hospital, Saskatoon, Saskatchewan, Canada.
Chest. 1988 Jul;94(1):178-80. doi: 10.1378/chest.94.1.178.
Late inflammatory sequelae following allergen (and occupational low molecular weight sensitizing chemical) exposure, including the late asthmatic response and increased nonallergic airway responsiveness, are now felt to be more important in the pathogenesis of atopic allergic and occupational asthma than are the early bronchospastic responses. These late sequelae can be inhibited by sodium cromoglycate and by corticosteroids but not by bronchodilators. Recognition that allergic and occupational (and likely all forms of) asthma are inflammatory conditions underscores the rationale for the early use of anti-inflammatory therapeutic strategies in the management of asthma. Such "anti-inflammatory" therapeutic strategies include environmental control, sodium cromoglycate, and both inhaled and oral corticosteroids.
变应原（以及职业性低分子量致敏化学物质）暴露后的迟发性炎症后遗症，包括迟发性哮喘反应和非变应性气道反应性增加，目前认为在特应性变应性和职业性哮喘的发病机制中比早期支气管痉挛反应更为重要。这些迟发性后遗症可被色甘酸钠和皮质类固醇抑制，但不能被支气管扩张剂抑制。认识到变应性和职业性（以及可能所有形式的）哮喘是炎症性疾病，突出了在哮喘管理中早期使用抗炎治疗策略的基本原理。此类“抗炎”治疗策略包括环境控制、色甘酸钠以及吸入和口服皮质类固醇。
