与慢性猫后睾吸虫感染相关的肝纤维化特征在叙利亚仓鼠和人类中。
Characteristics of liver fibrosis associated with chronic Opisthorchis felineus infection in Syrian hamsters and humans.
机构信息
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia.
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogova str., 1, Novosibirsk 630090, Russia; Institute of Molecular Biology and Biophysics, Akademika Timakova str., 2, Novosibirsk 630117, Russia.
出版信息
Exp Mol Pathol. 2019 Oct;110:104274. doi: 10.1016/j.yexmp.2019.104274. Epub 2019 Jun 19.
The food-borne liver trematode Opisthorchis felineus causes severe liver damage, including fibrosis. This study shows a comparison of the characteristics between cholangiofibrosis and periductal fibrosis in infected people and in the golden hamster as an experimental model. Comparative evaluation was carried out regarding collagen composition, the number of basic-producing cells, and extracellular-matrix degradation. The results revealed that characteristics of chronic opisthorchiasis due to O. felineus infection in humans and in Syrian hamsters are similar and include well-pronounced development of fibrotic complications in the liver parenchyma. Besides, a difference in fibrogenesis development was demonstrated between chronic O. felineus infection and noninfectious cholecystitis. In this study, we for the first time compared fibrogenesis between humans and model animals against the background of chronic O. felineus infection.
食源性肝吸虫华支睾吸虫可导致严重的肝损伤，包括纤维化。本研究比较了感染人群和实验模型金黄仓鼠的胆管纤维变性和围管性纤维变性的特征。对胶原组成、碱性成纤维细胞数量和细胞外基质降解进行了比较评价。结果表明，人类和叙利亚仓鼠华支睾吸虫感染所致慢性华支睾吸虫病的特征相似，包括肝实质纤维化并发症明显发展。此外，慢性华支睾吸虫感染与非传染性胆囊炎之间的纤维化发展也存在差异。在这项研究中，我们首次在慢性华支睾吸虫感染的背景下比较了人类和模型动物的纤维化。
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