Heath M J, Swannell A J, Williams C R, Palmer T
Department of Clinical Chemistry, City Hospital, Nottingham.
Ann Rheum Dis. 1987 Nov;46(11):823-6. doi: 10.1136/ard.46.11.823.
Thirty patients receiving gold therapy for rheumatoid arthritis (RA) were studied for the urinary excretion of gold. Statistical analysis of all the urine specimens passed over a period of four days by each patient showed that a definite rhythm of gold excretion exists for each patient which is possibly related to water excretion but not to creatinine excretion. The study indicates possible reasons for the inability of earlier workers to relate gold excretion to the general body gold status of patients and suggests that as the study of 24 hour excretions of gold may be an insensitive marker of gold excretion, closer examination of individual patient rhythms of gold excretion could possibly provide a more useful method of analysis.
对30名接受金疗法治疗类风湿性关节炎（RA）的患者的尿金排泄情况进行了研究。对每位患者在四天时间内排出的所有尿液样本进行统计分析后发现，每位患者都存在明确的金排泄节律，这可能与水的排泄有关，但与肌酐排泄无关。该研究指出了早期研究人员无法将金排泄与患者体内总体金状况联系起来的可能原因，并表明由于对24小时金排泄的研究可能是金排泄的一个不敏感指标，对个体患者金排泄节律进行更仔细的检查可能会提供一种更有用的分析方法。
