Billings R, Grahame R, Marks V, Wood P J, Taylor A
Rheumatol Rehabil. 1975 Feb;14(1):13-8. doi: 10.1093/rheumatology/14.1.13.
In this study the value of undertaking routine blood and urine estimations was assessed in relation to achieving maximum efficacy and safety in chrysotherapy. It was found that a favourable response to gold was forthcoming in approximately two-thirds of patients and occurred irrespective of the patients' disease duration or severity, or the mean serum gold level or the mean urinary gold excretion, estimated immediately before the next gold injection was due. The presence of rheumatoid nodules and the patients' advancing age were associated with a less favourable clinical response to gold. Those patients who derived a marked benefit from chrysotherapy did so significantly earlier in their course than those who derived only moderate benefit. A frequent correlation was seen in individual patients between serum gold levels and urinary gold excretion. This was most marked in those patients showing a favourable response to gold.
在本研究中，评估了进行常规血液和尿液检测对于在金疗法中实现最大疗效和安全性的价值。结果发现，大约三分之二的患者对金有良好反应，且该反应与患者的病程、病情严重程度、下次注射金之前即刻测得的平均血清金水平或平均尿金排泄量无关。类风湿结节的存在以及患者年龄的增长与对金的临床反应较差有关。从金疗法中获得显著益处的患者在病程中比仅获得中度益处的患者明显更早受益。在个体患者中，血清金水平和尿金排泄之间经常存在相关性。这在那些对金有良好反应的患者中最为明显。
