低出生体重、血压与肾脏易损性。
Low Birth Weight, Blood Pressure and Renal Susceptibility.
机构信息
Department of Physiology and Biophysics, Mississippi Center for Excellence in Perinatal Health, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Department of Pediatrics, Mississippi Center for Excellence in Perinatal Health, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
出版信息
Curr Hypertens Rep. 2019 Jun 21;21(8):62. doi: 10.1007/s11906-019-0969-0.
PURPOSE OF THE REVIEW
The purpose of this review is to highlight the clinical significance of increased renal risk that has its origins in fetal life. This review will also discuss the critical need to identify therapeutic interventions for use in a pregnancy complicated by placental dysfunction and intrauterine growth restriction that can mitigate the developmental origins of kidney disease without inflicting additional harm on the developing fetus.
RECENT FINDINGS
A reduction in nephron number is a contributory factor in the pathogenesis of hypertension and kidney disease in low birth weight individuals. Reduced nephron number may heighten susceptibility to a secondary renal insult, and recent studies suggest that perinatal history including birth weight should be considered in the assessment of renal risk in kidney donors. This review highlights current findings related to placental dysfunction, intrauterine growth restriction, increased risk for renal injury and disease, and potential therapeutic interventions.
目的综述
本文旨在强调起源于胎儿期的肾脏风险增加的临床意义。本综述还将讨论在胎盘功能障碍和宫内生长受限导致妊娠复杂化的情况下，迫切需要确定治疗干预措施，以减轻肾脏疾病的发育起源，而又不对发育中的胎儿造成额外伤害。
最新发现
出生体重低的个体中，肾单位数量减少是高血压和肾脏疾病发病机制的一个促成因素。肾单位数量减少可能会增加对继发性肾损伤的易感性，最近的研究表明，在评估肾脏供体的肾脏风险时，应考虑围产期病史，包括出生体重。本综述强调了与胎盘功能障碍、宫内生长受限、肾脏损伤和疾病风险增加以及潜在治疗干预措施相关的最新发现。
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