Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Curr Hypertens Rep. 2012 Dec;14(6):596-602. doi: 10.1007/s11906-012-0311-6.
A large body of literature suggests an inverse relationship between birth weight and blood pressure in children, adolescents and adults. The most persistent findings have been observed in children with a history of low birth weight or intrauterine growth restriction, while a large number of studies carried out in populations with normally distributed birth weight have shown conflicting results. A recently reported strong direct association between high birth weight and blood pressure, and the significant positive effect of postnatal growth on blood pressure suggests that the fetal origins of adult disease hypothesis should be expanded to include the role of excessive fetal and postnatal growth. In this paper, we review recent studies on the relationship between birth weight and blood pressure in childhood, with a focus on confounding variables that may explain the conflicting results of published work in this field.
大量文献表明，儿童、青少年和成年人的出生体重与血压之间呈负相关关系。在出生体重或宫内生长受限历史的儿童中观察到最持久的发现，而在具有正常分布出生体重的人群中进行的大量研究显示出相互矛盾的结果。最近报告的高出生体重与血压之间的强烈直接关联，以及出生后生长对血压的显著积极影响表明，成人疾病的胎儿起源假说应该扩大到包括胎儿和出生后过度生长的作用。在本文中，我们回顾了最近关于儿童期出生体重与血压之间关系的研究，重点讨论了可能解释该领域发表工作中相互矛盾结果的混杂变量。
