Luty A J, Mackenzie C D, Moloney N A
Wolfson Tropical Pathology, London School of Hygiene & Tropical Medicine, UK.
Br J Exp Pathol. 1987 Dec;68(6):825-38.
Secondary amyloidosis developed in various tissues of immunologically intact and T-cell deprived CBA mice infected with Schistosoma japonicum as indicated by histological, histochemical and immunofluorescence techniques. Mice deprived of T-cells were most susceptible both in terms of the timing of the onset of amyloidosis, first noted 6 weeks post-infection, and in terms of the incidence, reaching 100% 12 weeks post-infection. Amyloidosis developed later in the infection in immunologically intact mice, the incidence was lower and there was less extensive replacement of normal tissue compared with that seen in T-cell deprived mice. Amyloid-related changes were most noticeable in the spleen where there was replacement of both follicular and non-follicular tissue. In the liver, amyloid deposits caused hepatocellular atrophic changes and in the kidney, glomerular and interstitial deposits were observed. The relationships between immunological reactivity and amyloidosis during schistosome infection is discussed.
组织学、组织化学和免疫荧光技术表明，在感染日本血吸虫的免疫健全和T细胞缺乏的CBA小鼠的各种组织中发生了继发性淀粉样变性。就淀粉样变性发病时间而言，T细胞缺乏的小鼠最易感，感染后6周首次发现淀粉样变性；就发病率而言，感染后12周发病率达到100%。免疫健全的小鼠在感染后期发生淀粉样变性，发病率较低，与T细胞缺乏的小鼠相比，正常组织被替代的范围较小。淀粉样变性相关变化在脾脏最为明显，滤泡和非滤泡组织均被替代。在肝脏中，淀粉样沉积物导致肝细胞萎缩性变化，在肾脏中，观察到肾小球和间质沉积物。本文讨论了血吸虫感染期间免疫反应性与淀粉样变性之间的关系。
