Koch Lauren Gerard, Britton Steven L
Department of Physiology and Pharmacology, University of Toledo, Toledo, OH, USA.
Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Methods Mol Biol. 2019;2018:309-317. doi: 10.1007/978-1-4939-9581-3_15.
Variation in exercise capacity is a translationally powerful indicator for overall health and disease. Here we review the basic methods used for development of theoretically based and hypothesis-driven rat models that divide for both exercise capacity and numerous complex disease risks This rat model system was made by selectively breeding genetically heterogeneous rat populations for low and high performance on a speed ramped treadmill running test.
运动能力的差异是一个对整体健康和疾病具有强大转化意义的指标。在此，我们回顾用于开发基于理论和假设驱动的大鼠模型的基本方法，这些模型在运动能力和众多复杂疾病风险方面都有区分。这个大鼠模型系统是通过在速度递增的跑步机跑步测试中，对基因异质的大鼠群体进行选择性繁殖，以获得低性能和高性能的大鼠而建立的。
