Western Paraná State University, Department of Life Sciences, Postgraduate Program in Applied Health Sciences, Francisco Beltrão, PR, Brazil.
Western Paraná State University, Department of Life Sciences, Postgraduate Program in Applied Health Sciences, Francisco Beltrão, PR, Brazil.
Braz J Infect Dis. 2019 May-Jun;23(3):173-181. doi: 10.1016/j.bjid.2019.05.007. Epub 2019 Jun 20.
The prison system in Paraná, Brazil, is experiencing serious problems related to the increasing number of prisoners. Control of hepatitis C virus (HCV) has become more intense because the incarcerated population is considered a high-risk group for contagious diseases due to the favorable conditions found in prisons for the spread of these morbidities. The objective of this study was to identify features associated with hepatitis C infection among male prisoners in correctional institutions of Paraná state, Brazil.
This was a case-control study (27 cases and 54 controls) of men incarcerated in 11 penitentiaries in Paraná, Brazil. Information was obtained through a questionnaire in a cross-sectional epidemiological survey on HCV infection during the period from May 2015 to December 2016. Eligible men were recruited after testing positive for anti-HCV antibodies. Cases and controls were selected based on serological results of enzyme-linked immunosorbent assays and were matched by age, location of the penitentiary, and time in prison. Logistic regression analysis was used to identify risk factors for HCV seropositivity.
The main significant independent risk factor for the acquisition of HCV infection was the use of injectable drugs (OR = 4.00; 95%CI:1.41-11.35; p < 0.001).
This study provides evidence that HCV infection is associated with drug use by this population. This information is pivotal for tailoring prevention programs and guiding specific socioeducational measures that aim to reduce or prevent HCV transmission within the prison setting.
巴西巴拉那州的监狱系统正面临着与囚犯人数不断增加相关的严重问题。由于监狱内有利于传染病传播的条件，囚犯人群被视为传染病的高风险群体，因此对丙型肝炎病毒（HCV）的控制变得更加严格。本研究旨在确定与巴西巴拉那州监狱男性囚犯丙型肝炎感染相关的特征。
这是一项在巴西巴拉那州 11 所监狱中进行的男性囚犯病例对照研究（27 例病例和 54 例对照）。在 2015 年 5 月至 2016 年 12 月期间，通过横断面流行病学调查，使用问卷收集了关于 HCV 感染的信息。在抗 HCV 抗体检测呈阳性后，对合格的男性进行了招募。病例和对照是根据酶联免疫吸附试验的血清学结果选择的，并按年龄、监狱所在地和入狱时间进行匹配。使用逻辑回归分析确定 HCV 血清阳性的危险因素。
获得 HCV 感染的主要独立显著危险因素是使用注射毒品（OR=4.00；95%CI：1.41-11.35；p<0.001）。
本研究提供了证据表明 HCV 感染与该人群的药物使用有关。这些信息对于制定预防计划和指导特定的社会教育措施至关重要，这些措施旨在减少或预防监狱内 HCV 的传播。
