Department of Psychology, Brooklyn College of City University of New York, Brooklyn, NY 11210, USA.
Department of Psychology, Brooklyn College of City University of New York, Brooklyn, NY 11210, USA.
Physiol Behav. 2019 Sep 1;208:112586. doi: 10.1016/j.physbeh.2019.112586. Epub 2019 Jun 19.
The postoral actions of sugar and fat can rapidly stimulate the intake of and preference for flavors associated with these nutrients via a process known as appetition. Prior findings revealed that postoral glucose appetition is not attenuated following capsaicin-induced visceral deafferentation. The present experiment determined if capsaicin treatment altered fat appetition in C57BL/6 mice. Following capsaicin (Cap) or control (Con) treatment, mice were fitted with chronic intragastric (IG) catheters. They were then given 1-h sessions with a flavored saccharin solution (CS-) paired with IG water infusion or a different flavor (CS+) paired with IG 6.4% fat infusion. IG fat stimulated CS+ intakes in both Cap and Con mice, and the groups displayed similar preferences for CS+ over CS- in two-choice tests. These results confirm prior reports of normal fat conditioning in rats exposed to capsaicin or vagal deafferentation surgery. In contrast, other recent findings indicate that total or selective vagotomy alters the preference of mice for dilute vs. concentrated fat sources.
糖和脂肪的口腔作用可以通过一种被称为食欲的过程，快速刺激与这些营养物质相关的味道的摄入和偏好。先前的研究结果表明，在辣椒素引起的内脏去传入后，口腔葡萄糖食欲不会减弱。本实验确定了辣椒素处理是否改变了 C57BL/6 小鼠的脂肪食欲。在接受辣椒素（Cap）或对照（Con）处理后，小鼠被安装了慢性胃内（IG）导管。然后，他们进行了 1 小时的有风味的蔗糖溶液（CS-）与 IG 水输注或不同风味（CS+）与 IG 6.4%脂肪输注的配对实验。IG 脂肪刺激了 Cap 和 Con 小鼠的 CS+摄入，并且两组在双选择测试中对 CS+的偏好都高于 CS-。这些结果证实了先前关于暴露于辣椒素或迷走神经去传入手术后大鼠正常脂肪条件反射的报告。相比之下，其他最近的研究结果表明，总迷走神经切断或选择性迷走神经切断会改变小鼠对稀释与浓缩脂肪源的偏好。
