人类胚胎脑区的发育轨迹。
Developmental trajectories of the human embryologic brain regions.
机构信息
Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
出版信息
Neurosci Lett. 2019 Aug 24;708:134342. doi: 10.1016/j.neulet.2019.134342. Epub 2019 Jun 19.
Vertebrate brains commonly consist of five basic embryologic anatomical regions: telencephalon; diencephalon; mesencephalon; metencephalon; and myelencephalon. The proportions of these regions vary widely across species and developmental stages. Investigation of their growth trajectories, therefore, has the potential to provide an understanding of the substrates of inter-species variation in neuroanatomy and function. To investigate the volumetric growth trajectories, structural magnetic resonance imaging (MRI) scans obtained from 618 healthy children (334 boys, 284 girls; ages 3-17 years old) were parcellated into five regions for the volume quantification. The sex- and region-specific growth trajectories were identified, and the most active growth was seen in the mesencephalon for both boys and girls. Whether similar regional growth patterns are seen in other species, or whether such patterns are related to evolution, are important questions that must be elucidated in the future.
脊椎动物的大脑通常由五个基本的胚胎解剖区域组成
端脑、间脑、中脑、后脑和延髓。这些区域在物种和发育阶段的比例差异很大。因此，研究它们的生长轨迹有可能为理解神经解剖和功能的物种间变异提供基础。为了研究体积生长轨迹，对 618 名健康儿童（334 名男孩，284 名女孩；年龄 3-17 岁）的结构磁共振成像（MRI）扫描进行了分区，以对体积进行量化。确定了性别和区域特异性的生长轨迹，并且在男孩和女孩中，中脑的生长最为活跃。在其他物种中是否存在类似的区域生长模式，或者这种模式是否与进化有关，这些都是未来必须阐明的重要问题。
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