外泌体 miRNA 在癌症的化疗耐药、免疫逃逸、转移和进展中的作用。
Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer.
机构信息
National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air force station, Gandhinagar, 382355, Gujarat, India.
National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air force station, Gandhinagar, 382355, Gujarat, India; Department of Materials Science Engineering, Indian Institute of Technology-Jammu, Jagti, PO Nagrota, Jammu - 181 221, J&K, India.
出版信息
Drug Discov Today. 2019 Oct;24(10):2058-2067. doi: 10.1016/j.drudis.2019.06.010. Epub 2019 Jun 19.
In the treatment of cancer, there are three significant limitations causing high mortality and recurrence rates among cancer patients. First, the escape of tumor cells from the immune system; second, the development of multi-drug resistance (MDR) to chemotherapeutic drugs; and, third, the noxious metastases of cancer cells. Exosomes are vesicular cargos involved in the transportation of miRNA, mRNA and proteins from one cell to another cell. This review details the current understanding of the exosomal transmission of miRNA and crosstalk with the downstream consequences, ultimately leading to the progression and metastasis of cancer. Further, this review also discusses how exosomal miRNA can provide promising novel targets for the treatment and detection of cancer.
在癌症治疗中，有三个显著的局限性导致癌症患者的死亡率和复发率居高不下。首先，肿瘤细胞逃避免疫系统；其次，对化疗药物产生多药耐药性（MDR）；第三，癌细胞的有害转移。外泌体是一种囊泡货物，参与 miRNA、mRNA 和蛋白质从一个细胞到另一个细胞的运输。本综述详细介绍了对外泌体传递 miRNA 的现有认识，以及与下游后果的串扰，最终导致癌症的进展和转移。此外，本综述还讨论了外泌体 miRNA 如何为癌症的治疗和检测提供有前途的新靶点。
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