Dean McGee Eye Institute, Oklahoma City, Oklahoma, USA.
Wilmer Eye Institute, Baltimore, Maryland, USA.
Am J Ophthalmol. 2019 Nov;207:232-239. doi: 10.1016/j.ajo.2019.06.015. Epub 2019 Jun 21.
Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) can be used with sedation in children who are not amenable to traditional imaging. We report GCC and RNFL measurements in normal children using HH-OCT.
Prospective observational study of normal children ≤5 years of age.
Healthy, full-term children ≤5 years of age undergoing sedation or anesthesia were enrolled. Exclusion criteria included prematurity and pre-existing neurologic, genetic, metabolic, or intraocular pathology. Demographic data, axial length (Master-Vu Sonomed Escalon, Lake Success, New York, USA), and HH-OCT macular and optic nerve volume scans at 0° (Bioptigen, Inc., Morrisville, North Carolina, USA) were obtained. Retinal segmentation was completed with DOCTRAP software, creating average volume thickness maps.
Sixty-seven children (67 eyes, 31 males ranging in age from 3.4-70.9 months) were enrolled. Average axial length was 21.2 ± 1.0 mm with mean spherical equivalent +1.49 ± 1.34 diopters (range -2.25 to 4.25). Average GCC volume for the total retina was 0.28 ± 0.04 mm. Forty-seven of these eyes had RNFL analysis. Average RNFL thickness of the papillomacular bundle was 38.2 ± 9.5 μm. There was no correlation between GCC volume, RNFL thickness, patient age, or axial length.
Average GCC volume and RNFL thickness was stable from 6 months to 5 years of age. This study provides normative data for GCC and RNFL obtained by HH-OCT in healthy eyes of young children, to serve in evaluating those with optic neuropathies.
测量神经节细胞复合体（GCC），包括视网膜神经纤维（RNFL）、节细胞和内丛状层，可以与视神经疾病引起的视力丧失相关联。手持式光学相干断层扫描（HH-OCT）可用于镇静状态下不适合传统成像的儿童。我们报告了使用 HH-OCT 测量正常儿童的 GCC 和 RNFL。
对≤5 岁正常儿童进行前瞻性观察研究。
纳入健康、足月、≤5 岁接受镇静或麻醉的儿童。排除标准包括早产儿和先前存在的神经、遗传、代谢或眼内病变。获取人口统计学数据、眼轴长度（美国纽约州湖景的 Master-Vu Sonomed Escalon）和 HH-OCT 黄斑和视神经 0°容积扫描（美国北卡罗来纳州莫里斯维尔的 Bioptigen，Inc.）。使用 DOCTRAP 软件进行视网膜分段，创建平均体积厚度图。
共纳入 67 名儿童（67 只眼，31 名男性，年龄 3.4-70.9 个月）。平均眼轴长度为 21.2±1.0mm，平均等效球镜度数为+1.49±1.34 屈光度（范围-2.25 至 4.25）。整个视网膜的平均 GCC 体积为 0.28±0.04mm。其中 47 只眼进行了 RNFL 分析。视盘黄斑束的平均 RNFL 厚度为 38.2±9.5μm。GCC 体积、RNFL 厚度、患者年龄和眼轴长度之间无相关性。
从 6 个月到 5 岁，GCC 体积和 RNFL 厚度保持稳定。本研究为使用 HH-OCT 评估健康儿童年轻眼睛的 GCC 和 RNFL 提供了正常数据，用于评估视神经病变患者。
