菲咯啉-异烟肼杂化配体及其 Ag 和 Mn 配合物的合成与抗菌活性。
Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag and Mn complexes.
机构信息
Department of Chemistry, Maynooth University, Maynooth, County Kildare, Ireland.
The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, TU Dublin - City Campus, Kevin Street, Dublin 8, Ireland.
出版信息
Biometals. 2019 Aug;32(4):671-682. doi: 10.1007/s10534-019-00204-5. Epub 2019 Jun 22.
Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag and Mn complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)]NO, [Ag(1)]BF and Mn(1). Polymeric {[Ag(1)(NO)]} has 1:1 stoichiometry and forms upon infusion of CHCl into a DMSO solution of [Ag(1)]NO. {[Ag(1)(NO)]} was structurally characterized using X-ray crystallography. Metal-free 1 and its 1:2 complexes exhibit very good, broad-spectrum antimicrobial activity and are not excessively toxic to mammalian cells (A549 lineage).
酰腙配体，（Z）-N'-(6-氧代-1,10-菲啰啉-5(6H)-亚基)异烟酰腙，1 是由异烟肼（INH）和 1,10-菲啰啉-5,6-二酮（菲酮）之间的 1:1 席夫碱缩合反应形成的。Ag 和 Mn 与 1:2 的金属：配体化学计量比形成配合物：[Ag(1)]NO、[Ag(1)]BF 和 Mn(1)。具有 1:1 化学计量比的聚合物{[Ag(1)(NO)]}是在将 CHCl 注入 [Ag(1)]NO 的 DMSO 溶液中形成的。使用 X 射线晶体学对无金属的 1 和其 1:2 配合物进行了结构表征。金属游离的 1 及其 1:2 配合物表现出非常好的广谱抗菌活性，对哺乳动物细胞（A549 系）的毒性不太大。
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