Programa de Pós-graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Trop Med Int Health. 2019 Aug;24(8):1003-1010. doi: 10.1111/tmi.13282. Epub 2019 Jul 14.
To assess the spatial distribution of TB and malaria incidence, as well as their spatial association with each other, regardless of environmental and socio-economic factors commonly reported as determinants of both disease rates among the municipalities of Amazonas State, Brazil between 2012 and 2015.
Through an ecological approach considering municipalities of Amazonas, Brazil, as unit of analysis, a negative binomial regression model was used to assess association between malaria and TB rates, in which the dependent variable was the average municipal tuberculosis incidence rate.
Positive associations of overall malaria (β = 0.100 [CI = 0.032, 0.168], P = 0.004), P. vivax malaria (β = 0.115 [CI = 0.036, 0.195], P = 0.005), and P. falciparum malaria (β = 0.389 [CI = -0.0124, 0.791], P = 0.057) with TB rates were found, regardless of the sociodemographic factors included in the study.
In the Brazilian Amazon, TB and malaria are spatially associated. Therefore, it is very likely that co-infections also occur in this region, regardless of the HIV status.
评估 2012 年至 2015 年间巴西亚马逊州各市镇的结核病和疟疾发病率的空间分布情况，以及它们之间的空间关联，而不论环境和社会经济因素通常被报告为这两种疾病发病率的决定因素。
通过一种生态方法，将巴西亚马逊州的各市镇视为分析单位，使用负二项回归模型来评估疟疾和结核病发病率之间的关联，其中因变量是平均市级结核病发病率。
总体疟疾（β=0.100[CI=0.032, 0.168]，P=0.004）、间日疟（β=0.115[CI=0.036, 0.195]，P=0.005）和恶性疟（β=0.389[CI=-0.0124, 0.791]，P=0.057）与结核病发病率之间存在正相关，而与研究中纳入的社会人口因素无关。
在巴西亚马逊地区，结核病和疟疾具有空间相关性。因此，该地区极有可能存在合并感染，而不论 HIV 状况如何。
