胰岛素抵抗与甲状腺状态之间的性激素非依赖性关联——一项针对临床甲状腺功能正常的非肥胖、超重及肥胖2型糖尿病患者的基于性别的生化研究
"Sex hormone independent associations between insulin resistance and thyroid status -a gender based biochemical study on clinically euthyroid non-obese, overweight and obese type 2 diabetics''.
作者信息
Jayanthi Rajendran, Srinivasan Abu Raghavan
机构信息
Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri BalajiVidyapeeth (Deemed to be University Accredited with A Grade by NAAC), Pondicherry, 607402, India.
Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri BalajiVidyapeeth (Deemed to be University Accredited with A Grade by NAAC), Pondicherry, 607402, India.
出版信息
Diabetes Metab Syndr. 2019 May-Jun;13(3):2286-2291. doi: 10.1016/j.dsx.2019.05.017. Epub 2019 May 25.
AIM
Studies indicate that type 2 diabetes mellitus (T2DM) might contribute to the development of thyroid disorders (TD). However, few gender based reports are available describing therelationship between T2DM and TD in clinically euthyroid, anthropometry specified groups of type 2 diabetics. The aim of this study was to relategender based biochemical changes in anthropometry specified, clinically euthyroid type 2 diabetics.
METHODOLOGY
The study was carried out on clinically euthyroid type 2 diabetics (male n = 269; female n = 301) at a tertiary health care unit in Pondicherry, South India. Three groups were segregatedbased on Body mass Index: 153 non-obese type 2 diabetics (BMI = 18.5-24.99), 291 overweight type 2 diabetics (BMI = 25-29.99) and 126 obese type 2 diabetics (BMI ≥ 30). Biochemical parameters included glycated hemoglobin, insulin resistance, Cortisol and Thyroid profile.
RESULTS
The study had included clinically euthyroid type 2 diabetics (52.8% females and 47.2% males). Statistically significant associationsweredifferently observed between insulin resistance (dependent variable) andother independent variables, irrespective of sex hormone status. Total protein was negatively related in non -obese male type 2 diabetics (R = 0.780); Triiodothyronine was inversely associated in overweight males, whereas cortisol and the divalent cations (Zinc and Magnesium) depicted positive association (R = 0.555) in the same group (overweight), butcortisol in non -obese female type 2 diabeticswas negative (R = 0.742); Glycated hemoglobin and calcium exhibited positive relationshipin obese type 2 female diabetics (R = 0.771)..
CONCLUSION
Our study has revealed distinctive relationship between T2DM and TD in the anthropometry specified, clinically euthyroid and gender based type 2 diabetics, independent of the sex hormones.
目的
研究表明，2型糖尿病（T2DM）可能促使甲状腺疾病（TD）的发生。然而，关于临床甲状腺功能正常、按人体测量指标分类的2型糖尿病患者中T2DM与TD之间关系的基于性别的报告却很少。本研究的目的是探讨按人体测量指标分类、临床甲状腺功能正常的2型糖尿病患者中基于性别的生化变化。
方法
本研究在印度南部本地治里的一家三级医疗保健机构对临床甲状腺功能正常的2型糖尿病患者（男性269例；女性301例）进行。根据体重指数将患者分为三组：153例非肥胖2型糖尿病患者（BMI = 18.5 - 24.99）、291例超重2型糖尿病患者（BMI = 25 - 29.99）和126例肥胖2型糖尿病患者（BMI≥30）。生化参数包括糖化血红蛋白、胰岛素抵抗、皮质醇和甲状腺指标。
结果
本研究纳入了临床甲状腺功能正常的2型糖尿病患者（女性占52.8%，男性占47.2%）。无论性激素状态如何，胰岛素抵抗（因变量）与其他自变量之间在统计学上存在显著不同的关联。总蛋白在非肥胖男性2型糖尿病患者中呈负相关（R = 0.780）；三碘甲状腺原氨酸在超重男性中呈负相关，而皮质醇与二价阳离子（锌和镁）在同一组（超重）中呈正相关（R = 0.555），但皮质醇在非肥胖女性2型糖尿病患者中呈负相关（R = 0.742）；糖化血红蛋白和钙在肥胖2型女性糖尿病患者中呈正相关（R = 0.771）。
结论
我们的研究揭示了在按人体测量指标分类、临床甲状腺功能正常且基于性别的2型糖尿病患者中，T2DM与TD之间存在独特的关系，且与性激素无关。
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