绝经前和绝经后女性的甲状腺状态——对非肥胖、超重和肥胖2型糖尿病患者胰岛素抵抗的生化研究

Thyroid status in premenopausal and postmenopausal women - A biochemical study on insulin resistance in non obese, overweight and obese type 2 diabetics.

作者信息

Jayanthi Rajendran, Srinivasan Abu Raghavan, Niranjan Gopal

机构信息

Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth (Deemed University accredited by NAAC with A Grade), Pondicherry, 607402, India.

出版信息

Diabetes Metab Syndr. 2018 Nov;12(6):859-862. doi: 10.1016/j.dsx.2018.05.001. Epub 2018 May 10.

DOI:10.1016/j.dsx.2018.05.001

PMID:29778669

Abstract

BACKGROUND

Insulin resistance with altered thyroid status in women is observed in type 2 diabetics and varies with advancing age and estrogen profile. We compared thyroid status between premenopausal and postmenopausal women in obese, non obese and overweight type 2 diabetes.

METHODOLOGY

We included 301type 2 diabetics who were segregated into premenopausal (n = 100) 33.2% and postmenopausal (n = 201) 66.8% among three sub groups (Non obese, overweight and Obese).Anthropometry, fasting blood glucose, lipid profile, glycated hemoglobin, homeostasis model assessment of insulin resistance, liver function tests, Free T4, T3, TSH, Znand Mg were enabled.

RESULTS

Non obese type 2 diabetics were segregated into two groups n = 21 (29.2%)- premenopausal with mean age of 41.48 ± 4.30 and n = 51 (70.8%) - post menopausal with mean age of 58.49 ± 7.32 There were significant differences in WHR, HbA1c, HDL with p < 0.05 and ALP with p < 0.01; Overweight type 2 diabetics n = 55 (37.9%) -premenopausal with mean age of 41.96 ± 3.80 and n = 90 (62.1%)- post menopausal with mean age of 57.80 ± 7.20. There were significant differences in Urea, Zinc, Total protein, Albumin with p < 0.05 and T4, TSH with p < 0.01. Obese Type 2 diabetics n = 24 (28.6%) -premenopausal with mean age of 42.00 ± 4.30 and n = 60 (71.4%) -post menopausal with mean age of 57.80 ± 7.20. There were significant differences in Urea, Magnesium, Triacylglycerols, and VLDL with p < 0.05, Insulin and HOMA-IR with p < 0.01.

CONCLUSION

Anthropometry specified classification of type 2 diabetics in pre and postmenopausal women reflects thyroid status.

摘要

背景

在2型糖尿病女性中观察到甲状腺状态改变伴胰岛素抵抗，且其随年龄增长和雌激素水平而变化。我们比较了肥胖、非肥胖和超重的2型糖尿病绝经前和绝经后女性的甲状腺状态。

方法

我们纳入了301例2型糖尿病患者，将其分为绝经前（n = 100，33.2%）和绝经后（n = 201，66.8%）两组，分属三个亚组（非肥胖、超重和肥胖）。进行了人体测量、空腹血糖、血脂谱、糖化血红蛋白、胰岛素抵抗稳态模型评估、肝功能检查、游离T4、T3、促甲状腺激素、锌和镁的检测。

结果

非肥胖的2型糖尿病患者分为两组，n = 21（29.2%）为绝经前，平均年龄41.48±4.30岁；n = 51（70.8%）为绝经后，平均年龄58.49±7.32岁。腰臀比、糖化血红蛋白、高密度脂蛋白有显著差异，p < 0.05，碱性磷酸酶有显著差异，p < 0.01；超重的2型糖尿病患者n = 55（37.9%）为绝经前，平均年龄41.96±3.80岁；n = 90（62.1%）为绝经后，平均年龄57.80±7.20岁。尿素、锌、总蛋白、白蛋白有显著差异，p < 0.05，甲状腺素、促甲状腺激素有显著差异，p < 0.01。肥胖的2型糖尿病患者n = 24（2