• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

17 年时间趋势和结果分析:钝性肝脾损伤的非手术治疗。

Non-operative management of blunt hepatic and splenic injury: a time-trend and outcome analysis over a period of 17 years.

机构信息

1Department of Visceral, Transplantation and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.

2Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria.

出版信息

World J Emerg Surg. 2019 Jun 17;14:29. doi: 10.1186/s13017-019-0249-y. eCollection 2019.

DOI:10.1186/s13017-019-0249-y
PMID:31236129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6580509/
Abstract

BACKGROUND

A widespread shift to non-operative management (NOM) for blunt hepatic and splenic injuries has been observed in most centers worldwide. Furthermore, many countries introduced safety measures to systematically reduce severe traffic and leisure sports injuries. This study aims to evaluate the effect of these nationwide implementations on individual patient characteristics and outcomes through a time-trend analysis over 17 years in an Austrian high-volume trauma center.

METHODS

A retrospective review of all emergency trauma patients admitted to the Medical University of Innsbruck from 2000 to 2016. Injury severity, clinical data on admission, operative and non-operative treatment parameters, complications, and in-hospital mortality were evaluated.

RESULTS

In total, 731 patients were treated with blunt hepatic and/or splenic injuries. Among these, 368 had a liver injury, 280 splenic injury, and 83 combined hepatic/splenic injury. Initial NOM was performed in 82.6% of all patients (93.5% in hepatic and 71.8% in splenic injuries) with a success rate of 96.7%. The secondary failure rate of NOM was 3.3% and remained consistent over 17 years ( = 0.515). In terms of injury severity, we observed a reduction over time, resulting in an overall mortality rate of 4.8% and 3.5% in the NOM group (decreasing from 7.5 to 1.9% and from 5.6 to 1.3%, respectively). These outcomes confirmed an improved utilization of the NOM approach.

CONCLUSION

Our cohort represents one of the largest Central European single-center experiences available in the literature. NOM is the standard of care for blunt hepatic and splenic injuries and successful in > 96% of all patients. This rate was quite constant over 17 years ( = 0.515). Overall, national and regional safety measures resulted in a significantly decreased severity of observed injury patterns and deaths due to blunt hepatic or splenic trauma. Although surgery is nowadays only applied in about one third of splenic injury patients in our center, these numbers might further decrease by intensified application of interventional radiology and modern coagulation management.

摘要

背景

在世界范围内,大多数中心已广泛采用非手术治疗(NOM)治疗钝性肝脾损伤。此外,许多国家引入了安全措施,以系统减少严重的交通和休闲运动损伤。本研究旨在通过在奥地利一家大容量创伤中心进行的 17 年时间趋势分析,评估这些全国性实施对个体患者特征和结果的影响。

方法

回顾性分析 2000 年至 2016 年期间入住因斯布鲁克医科大学的所有急诊创伤患者。评估损伤严重程度、入院时的临床数据、手术和非手术治疗参数、并发症和院内死亡率。

结果

共有 731 例患者接受了钝性肝脾损伤治疗。其中 368 例为肝损伤,280 例为脾损伤,83 例为肝脾联合损伤。所有患者中,初始 NOM 治疗的比例为 82.6%(肝损伤为 93.5%,脾损伤为 71.8%),成功率为 96.7%。NOM 的继发失败率为 3.3%,且在 17 年内保持不变(=0.515)。就损伤严重程度而言,我们观察到随着时间的推移有所降低,导致总体死亡率为 4.8%,NOM 组为 3.5%(分别从 7.5%降至 1.9%,从 5.6%降至 1.3%)。这些结果证实了 NOM 方法的应用得到了改善。

结论

我们的队列代表了文献中可获得的最大的中欧单中心经验之一。NOM 是治疗钝性肝脾损伤的标准方法,在所有患者中的成功率超过 96%。在 17 年内,这一比例相当稳定(=0.515)。总体而言,国家和地区安全措施导致因钝性肝或脾创伤导致的损伤模式和死亡严重程度显著降低。虽然在我们中心,现在只有约三分之一的脾损伤患者需要手术治疗,但通过强化介入放射学和现代凝血管理的应用,这些数字可能会进一步下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33dc/6580509/04115e81269b/13017_2019_249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33dc/6580509/01ad1fb5831f/13017_2019_249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33dc/6580509/04115e81269b/13017_2019_249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33dc/6580509/01ad1fb5831f/13017_2019_249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33dc/6580509/04115e81269b/13017_2019_249_Fig2_HTML.jpg

相似文献

1
Non-operative management of blunt hepatic and splenic injury: a time-trend and outcome analysis over a period of 17 years.17 年时间趋势和结果分析:钝性肝脾损伤的非手术治疗。
World J Emerg Surg. 2019 Jun 17;14:29. doi: 10.1186/s13017-019-0249-y. eCollection 2019.
2
Clinical parameters for the early detection of complications in patients with blunt hepatic and/or splenic injury undergoing non-operative management.用于检测行非手术治疗的钝性肝和/或脾损伤患者并发症的临床参数。
Eur J Trauma Emerg Surg. 2024 Jun;50(3):847-855. doi: 10.1007/s00068-024-02460-8. Epub 2024 Jan 31.
3
Blunt splenic injuries: dedicated trauma surgeons can achieve a high rate of nonoperative success in patients of all ages.钝性脾损伤:专业创伤外科医生在各年龄段患者中均可实现较高的非手术成功率。
J Trauma. 2000 May;48(5):801-5; discussion 805-6. doi: 10.1097/00005373-200005000-00002.
4
The role of grade of injury in non-operative management of blunt hepatic and splenic trauma: Case series from a multicenter experience.损伤分级在钝性肝脾创伤非手术治疗中的作用:多中心经验的病例系列
Medicine (Baltimore). 2019 Aug;98(35):e16746. doi: 10.1097/MD.0000000000016746.
5
Validation of the revised 2018 AAST-OIS classification and the CT severity index for prediction of operative management and survival in patients with blunt spleen and liver injuries.验证修订后的 2018AAST-OIS 分类和 CT 严重指数在预测钝性脾和肝损伤患者手术治疗和生存中的作用。
Eur Radiol. 2020 Dec;30(12):6570-6581. doi: 10.1007/s00330-020-07061-8. Epub 2020 Jul 21.
6
Management of blunt hepatic and splenic trauma in a Greek level I trauma centre.希腊一级创伤中心钝性肝脾创伤的管理
Acta Chir Belg. 2006 Sep-Oct;106(5):566-71. doi: 10.1080/00015458.2006.11679953.
7
[Associated factors to non-operative management failure of hepatic and splenic lesions secondary to blunt abdominal trauma in children].[儿童钝性腹部创伤继发肝脾损伤非手术治疗失败的相关因素]
Rev Chil Pediatr. 2017;88(4):470-477. doi: 10.4067/S0370-41062017000400005.
8
Hospital level variations in the trends and outcomes of the nonoperative management of splenic injuries - a nationwide cohort study.医院层面上脾损伤非手术治疗趋势和结局的变化:一项全国性队列研究。
Scand J Trauma Resusc Emerg Med. 2019 Jan 11;27(1):4. doi: 10.1186/s13049-018-0578-y.
9
Non operative management of blunt splenic trauma: a prospective evaluation of a standardized treatment protocol.钝性脾外伤的非手术治疗:一项标准化治疗方案的前瞻性评估
Eur J Trauma Emerg Surg. 2016 Oct;42(5):593-598. doi: 10.1007/s00068-015-0575-z. Epub 2015 Sep 28.
10
Non-operative management of solid organ injuries in a middle-income country, how does it stack up?中低收入国家的实体器官损伤非手术治疗:情况如何?
Injury. 2022 Sep;53(9):2992-2997. doi: 10.1016/j.injury.2022.03.036. Epub 2022 Mar 26.

引用本文的文献

1
Prevalence, characteristics and treatment of concomitant injury to liver and spleen with vascular injury after blunt abdominal trauma.钝性腹部创伤后肝脾伴血管损伤的发生率、特征及治疗
Sci Rep. 2025 Aug 7;15(1):28972. doi: 10.1038/s41598-025-14113-w.
2
Long-term follow-up of infection, malignancy, thromboembolism, and all-cause mortality risks after splenic artery embolization for blunt splenic injury: comparison with splenectomy and conservative management.钝性脾损伤行脾动脉栓塞术后感染、恶性肿瘤、血栓栓塞及全因死亡风险的长期随访:与脾切除术及保守治疗的比较
BJS Open. 2025 Mar 4;9(2). doi: 10.1093/bjsopen/zraf037.
3

本文引用的文献

1
Non-Operative Management of Blunt Liver Trauma: Safety, Efficacy and Complications of a Standardized Treatment Protocol.钝性肝损伤的非手术治疗:标准化治疗方案的安全性、有效性及并发症
Bull Emerg Trauma. 2019 Jan;7(1):49-54. doi: 10.29252/beat-070107.
2
Non-operative management of blunt hepatic and splenic injuries-practical aspects and value of radiological scoring systems.钝性肝脾损伤的非手术治疗——放射学评分系统的实践要点与价值
Eur Surg. 2018;50(6):285-298. doi: 10.1007/s10353-018-0545-x. Epub 2018 Jul 20.
3
Blunt liver trauma: a descriptive analysis from a level I trauma center.
Risk factors of 180-day rebleeding after management of blunt splenic injury without surgery and embolization: a national database study.
非手术及栓塞治疗钝性脾损伤后180天再出血的危险因素:一项全国性数据库研究
World J Emerg Surg. 2025 Feb 5;20(1):11. doi: 10.1186/s13017-025-00586-7.
4
Surgical registrars' exposure to trauma laparotomy: A retrospective study from a level 1 trauma centre in New Zealand.外科住院医师参与创伤剖腹手术情况:来自新西兰一家一级创伤中心的回顾性研究。
Surg Pract Sci. 2022 May 24;9:100091. doi: 10.1016/j.sipas.2022.100091. eCollection 2022 Jun.
5
Potential new treatment for inferior vena cava injury using extracorporeal membrane oxygenation applying flow diversion effect.利用体外膜肺氧合的血流分流效应治疗下腔静脉损伤的潜在新疗法。
Trauma Surg Acute Care Open. 2024 Nov 18;9(1):e001618. doi: 10.1136/tsaco-2024-001618. eCollection 2024.
6
The negative effect of preexisting cirrhosis on blunt liver trauma patients: a multifaceted approach from the trauma quality improvement program database.预先存在的肝硬化对钝性肝外伤患者的负面影响:创伤质量改进计划数据库的多方面方法。
Eur J Trauma Emerg Surg. 2024 Oct;50(5):2209-2217. doi: 10.1007/s00068-024-02655-z. Epub 2024 Sep 3.
7
Surgical Treatment versus Conservative Management of Splenic Rupture: Outcomes and Risk Factors.脾破裂的手术治疗与保守治疗:结果与风险因素
Bull Emerg Trauma. 2024;12(1):15-20. doi: 10.30476/BEAT.2024.101350.1489.
8
IPR1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin.IPR1介导的线粒体相关内质网膜(MAMs)形成促成机械性创伤诱导的肝损伤以及褪黑素的保护作用。
Cell Mol Biol Lett. 2024 Feb 2;29(1):22. doi: 10.1186/s11658-023-00509-x.
9
Effects of laparoscopic splenectomy on surgical site wound infection in patients with spleen rupture: A meta-analysis.腹腔镜脾切除术对脾破裂患者手术部位伤口感染的影响:一项荟萃分析。
Int Wound J. 2023 Oct 23;21(2). doi: 10.1111/iwj.14440.
10
Abdominal pain is a main manifestation of delayed bleeding after splenic injury in patients receiving non-operative management.腹痛是脾损伤非手术治疗患者延迟性出血的主要表现。
Sci Rep. 2022 Nov 18;12(1):19871. doi: 10.1038/s41598-022-24399-9.
钝性肝外伤:来自一级创伤中心的描述性分析
BMC Surg. 2018 Jun 19;18(1):42. doi: 10.1186/s12893-018-0369-4.
4
Classification of the severe trauma patient with the Abbreviated Injury Scale: degree of correlation between versions 98 and 2005 (2008 update).创伤严重度分类的简明损伤定级法:98 版与 2005 版(2008 年更新)的相关性程度。
Emergencias. 2018 Feb;30(1):41-44.
5
Transfusion Approaches and Mortality in Trauma Patients: A Narrative Review.创伤患者的输血方法与死亡率:一项叙述性综述
Semin Thromb Hemost. 2017 Oct;43(7):759-771. doi: 10.1055/s-0037-1605570. Epub 2017 Sep 11.
6
Splenic trauma: WSES classification and guidelines for adult and pediatric patients.脾脏创伤:WSES 分类和成人及儿童患者治疗指南。
World J Emerg Surg. 2017 Aug 18;12:40. doi: 10.1186/s13017-017-0151-4. eCollection 2017.
7
Early fibrinogen-concentrate administration in management of trauma-induced coagulopathy - Authors' reply.创伤性凝血病管理中早期给予纤维蛋白原浓缩物——作者回复
Lancet Haematol. 2017 Aug;4(8):e348-e349. doi: 10.1016/S2352-3026(17)30126-6.
8
Trends in nonoperative management of traumatic injuries - A synopsis.创伤性损伤非手术治疗的趋势——概述
Int J Crit Illn Inj Sci. 2017 Jan-Mar;7(1):38-57. doi: 10.4103/IJCIIS.IJCIIS_7_17.
9
Treatment of Liver Trauma: Operative or Conservative Management.肝外伤的治疗:手术治疗还是保守治疗。
Gastroenterology Res. 2010 Feb;3(1):9-18. doi: 10.4021/gr2010.02.165w. Epub 2010 Jan 20.
10
Nonoperative management of blunt hepatic trauma: A systematic review.钝性肝外伤的非手术治疗:一项系统评价。
J Trauma Acute Care Surg. 2015 Oct;79(4):654-60. doi: 10.1097/TA.0000000000000814.