Freeman Morganna, Laks Shachar
Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Department of Surgery, East Carolina University, Greenville, NC 27834, USA.
Melanoma Manag. 2019 Apr 18;6(1):MMT12. doi: 10.2217/mmt-2019-0003. eCollection 2019 Mar.
Most patients newly diagnosed with melanoma have early-stage disease considered of good prognosis. However, with a risk of recurrence, appropriate follow-up may include surveillance imaging for early relapse detection. Previously, surveillance imaging to detect recurrences was considered unjustified, given the lack of effective treatments. Now, systemic therapies have improved, and patients with low tumor burden may derive benefit from surveillance imaging. Despite this, controversy exists regarding the role of surveillance imaging in early-stage melanoma survivorship, in part reflected by the lack of consensus on specific imaging protocols and broad guidelines. This review discusses published evidence on surveillance imaging to detect metastasis in high-risk melanoma, the need for early recurrence detection and implications for value-based clinical decision-making, survivorship care and multidisciplinary patient management.
大多数新诊断为黑色素瘤的患者患有预后良好的早期疾病。然而,鉴于存在复发风险,适当的随访可能包括进行监测成像以早期发现复发。以前,鉴于缺乏有效的治疗方法,检测复发的监测成像被认为是不合理的。现在,全身治疗已有改善,肿瘤负荷低的患者可能从监测成像中获益。尽管如此,监测成像在早期黑色素瘤生存中的作用仍存在争议,部分原因是在具体成像方案和广泛指南方面缺乏共识。本综述讨论了已发表的关于监测成像以检测高危黑色素瘤转移的证据、早期复发检测的必要性以及对基于价值的临床决策、生存护理和多学科患者管理的影响。