Morgantetti Giuliano Ferreira, Balancin Marcelo Luiz, de Medeiros Guilherme Alencar, Dantas Márcio, Silva Gyl Eanes Barros
University of São Paulo (USP), Ribeirão Preto, Brazil.
University of São Paulo (USP), São Paulo, Brazil.
Transl Androl Urol. 2019 May;8(Suppl 2):S192-S197. doi: 10.21037/tau.2018.10.14.
Cytomegalovirus (CMV) is an important cause of renal transplantation complications. It can cause different syndromes or end-organ diseases that can lead to unfavourable clinical outcomes and kidney allograft dysfunction. Although well documented as a systemic disease on renal transplant patients, affecting non-renal tissue, as gastrointestinal and respiratory tract, few cases have been reported in English-language indexed journals involving renal allograft lesions secondary to CMV. As an important differential diagnosis and etiological agent to acute and chronic rejection, the possibility of CMV kidney direct infection needs prompt recognition for effective treatment. In this paper, we will review the current literature about CMV nephritis and discuss the findings from each case report.
巨细胞病毒(CMV)是肾移植并发症的一个重要原因。它可引发不同的综合征或终末器官疾病,进而导致不良的临床结局和肾移植功能障碍。尽管CMV作为一种累及肾移植患者非肾组织(如胃肠道和呼吸道)的全身性疾病已有充分记载,但英文索引期刊报道的继发于CMV的肾移植病变病例却很少。作为急慢性排斥反应的重要鉴别诊断和病因,CMV直接感染肾脏的可能性需要得到及时识别以便进行有效治疗。在本文中,我们将回顾有关CMV肾炎的当前文献,并讨论各病例报告的研究结果。