Halpin D M, Charlton H M
Department of Human Anatomy, University of Oxford, U.K.
J Reprod Fertil. 1988 Jan;82(1):393-400. doi: 10.1530/jrf.0.0820393.
Twice daily injections of purified ovine and human FSH were used to investigate the control of ovarian follicle development in hypogonadotrophic hypogonadal (hpg) mice. Treatment for 5 days with doses greater than 3 micrograms resulted in a significant increase in the total number of growing follicles and the development of antral follicles. This was associated with increases in uterine weights and vaginal opening, indicating that steroidogenesis had also been stimulated. Further studies of the effects of combined injections of FSH and LH, linked with morphological analysis of ovarian interstitial cells, suggested that any contribution of background or contaminating LH to the effects of the FSH injections was minimal. It therefore appears that, in mice, FSH alone is capable of stimulating an increase in the initiation of follicle growth, of triggering the development of antral follicles, and supporting ovarian steroidogenesis.
每日两次注射纯化的羊促卵泡素（FSH）和人促卵泡素，以研究促性腺激素低下性性腺功能减退（hpg）小鼠卵巢卵泡发育的调控机制。用大于3微克的剂量治疗5天，导致生长卵泡总数显著增加以及窦状卵泡的发育。这与子宫重量增加和阴道开口有关，表明类固醇生成也受到了刺激。对促卵泡素（FSH）和促黄体生成素（LH）联合注射效果的进一步研究，结合卵巢间质细胞的形态学分析，表明背景或污染的促黄体生成素（LH）对促卵泡素（FSH）注射效果的任何贡献都微乎其微。因此，在小鼠中，单独的促卵泡素（FSH）似乎能够刺激卵泡生长起始增加、触发窦状卵泡发育并支持卵巢类固醇生成。
