Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Shanghai, 200025, China.
Clin Rheumatol. 2019 Nov;38(11):3205-3210. doi: 10.1007/s10067-019-04642-x. Epub 2019 Jun 21.
To evaluate the serum levels of the anti-inflammatory cytokine interleukin-10 (IL-10) in patients with adult-onset Still's disease (AOSD), a rare, systemic, and multigenic inflammatory disease. The serum levels of IL-10, IL-1β, IL-6, IL-18, and TNF-α were examined by electrochemiluminescence assay. The serum levels of IL-10 were higher in AOSD patients than in healthy controls and positively correlated with systemic score, erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), ferritin, and inflammatory cytokine (IL-1β, IL-6, IL-18, and TNF-α) levels. Moreover, the levels of IL-10 were significantly higher in AOSD patients who had fever, sore throat, rash, lymphadenopathy, splenomegaly, pneumonia, and arthralgia than in patients who did not. IL-10 was increased in AOSD patients and correlated with disease activity. KEY POINTS: • In this manuscript, we confirmed the elevated serum levels of the anti-inflammatory cytokine IL-10 in AOSD patients, which was previously poorly defined. • We revealed for the first time that the levels of IL-10 were correlated with disease activity and inflammatory cytokine levels in AOSD.
为了评估成人Still 病（AOSD）患者血清中抗炎细胞因子白细胞介素-10（IL-10）的水平，这是一种罕见的全身性多基因炎症性疾病。采用电化学发光法检测 IL-10、IL-1β、IL-6、IL-18 和 TNF-α的血清水平。AOSD 患者的血清 IL-10 水平高于健康对照组，且与全身评分、红细胞沉降率（ESR）、C 反应蛋白水平（CRP）、铁蛋白和炎症细胞因子（IL-1β、IL-6、IL-18 和 TNF-α）水平呈正相关。此外，发热、咽痛、皮疹、淋巴结肿大、脾肿大、肺炎和关节痛的 AOSD 患者的 IL-10 水平明显高于无这些症状的患者。IL-10 在 AOSD 患者中升高，并与疾病活动度相关。要点：• 在本研究中，我们证实了 AOSD 患者血清中抗炎细胞因子 IL-10 的水平升高，此前对此认识不足。• 我们首次发现 AOSD 患者的 IL-10 水平与疾病活动度和炎症细胞因子水平相关。
