Department of Rheumatology and Immunology, Ruijin Hospital.
Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Rheumatology (Oxford). 2020 Nov 1;59(11):3293-3302. doi: 10.1093/rheumatology/keaa135.
Triggering receptor expressed on myeloid cells-1 (TREM-1) is an amplifier of inflammatory signals. Recently, a soluble form of TREM-1 (sTREM-1) was described. This study aimed to investigate the role of serum sTREM-1 in patients with adult-onset Still's disease (AOSD).
Serum sTREM-1 levels were detected in 108 AOSD patients, 88 RA patients and 112 healthy controls (HC). The correlations of sTREM-1 with disease activity, clinical characteristics and laboratory parameters in AOSD patients were analysed by the Spearman correlation test. Risk factors for the chronic course of AOSD were evaluated by multivariate logistic regression analysis.
AOSD patients had significantly higher serum sTREM-1 levels than RA patients and HC, and serum sTREM-1 levels were correlated with the systemic score, ferritin, leucocyte count, CRP, IL-1β and IL-6. The elevation in the initial sTREM-1 level by itself could discriminate patients developing the chronic course from patients developing the nonchronic course. Moreover, an elevated sTREM-1 level (> 526.4475 pg/ml) was an independent risk factor for the chronic course in active AOSD patients. Furthermore, interfering with TREM-1 engagement led to reductions in the secretion of pro-inflammatory cytokines, such as IL-1β, IL-6 and TNF-α, in neutrophils and monocytes from active AOSD patients.
Serum sTREM-1 levels are correlated with disease activity, and an elevation in the initial serum sTREM-1 level is a potential predictor of the chronic course in AOSD patients, which currently provides the best predictive model for identifying patients prone to developing the chronic course of AOSD.
髓系细胞触发受体-1（TREM-1）是炎症信号的放大器。最近，描述了 TREM-1 的可溶性形式（sTREM-1）。本研究旨在探讨血清 sTREM-1 在成人Still 病（AOSD）患者中的作用。
检测了 108 例 AOSD 患者、88 例 RA 患者和 112 例健康对照者（HC）的血清 sTREM-1 水平。采用 Spearman 相关检验分析 sTREM-1 与 AOSD 患者疾病活动度、临床特征和实验室参数的相关性。采用多因素 logistic 回归分析评估 AOSD 慢性病程的危险因素。
AOSD 患者的血清 sTREM-1 水平明显高于 RA 患者和 HC，血清 sTREM-1 水平与全身评分、铁蛋白、白细胞计数、CRP、IL-1β和 IL-6 相关。初始 sTREM-1 水平升高本身可区分发生慢性病程的患者和发生非慢性病程的患者。此外，在活动期 AOSD 患者中，升高的 sTREM-1 水平（>526.4475 pg/ml）是慢性病程的独立危险因素。此外，干扰 TREM-1 结合可导致来自活动期 AOSD 患者的中性粒细胞和单核细胞中促炎细胞因子（如 IL-1β、IL-6 和 TNF-α）的分泌减少。
血清 sTREM-1 水平与疾病活动度相关，初始血清 sTREM-1 水平升高是 AOSD 患者慢性病程的潜在预测指标，目前提供了识别易发生 AOSD 慢性病程患者的最佳预测模型。
