Ishdorj Ganchimeg, Beiggi Sara, Nugent Zoann, Streu Erin, Banerji Versha, Dhaliwal Dhali, Mahmud Salah M, Marshall Aaron J, Gibson Spencer B, Wiseman Marni C, Johnston James B
CancerCare Manitoba Research Institute (formerly, Manitoba Institute of Cell Biology), University of Manitoba, Winnipeg, Canada.
Department of Epidemiology and Cancer Registry, CancerCare Manitoba, Winnipeg, Canada.
Leuk Lymphoma. 2019 Dec;60(13):3204-3213. doi: 10.1080/10428194.2019.1620941. Epub 2019 Jun 25.
A retrospective analysis on 587 patients with chronic lymphocytic leukemia (CLL) assessed risk factors for skin cancer and the influence of skin cancers on survival and incidence of solid tumors (STs). Patients underwent skin surveillance and were followed for a median of 6.65 years. The relative risk for skin cancer increased prior to CLL diagnosis rising 4-fold one-year post-diagnosis. Independent predictors for skin cancer were male gender ( = .0001), age ≥70 years ( = .0036) and prior chemotherapy ( = .0116). There was no increase in mortality from skin cancer and neither skin cancer nor chemotherapy increased the risk for a ST. The development of a ST was an independent predictor of survival ( < .0001) and 43% of deaths were related to STs. Thus, regular skin surveillance can prevent increased mortality from skin cancer, but not STs, in CLL. Close skin monitoring is required for elderly males who received chemotherapy.
对587例慢性淋巴细胞白血病（CLL）患者进行回顾性分析，评估皮肤癌的危险因素以及皮肤癌对生存和实体瘤（STs）发生率的影响。患者接受皮肤监测，中位随访时间为6.65年。在CLL诊断之前，皮肤癌的相对风险增加，诊断后1年上升4倍。皮肤癌的独立预测因素为男性（P = 0.0001）、年龄≥70岁（P = 0.0036）和既往化疗（P = 0.0116）。皮肤癌死亡率没有增加，皮肤癌和化疗均未增加STs的风险。STs的发生是生存的独立预测因素（P < 0.0001），43%的死亡与STs相关。因此，定期皮肤监测可预防CLL患者皮肤癌死亡率增加，但不能预防STs。接受化疗的老年男性需要密切的皮肤监测。
