Walz Juliane Sarah, Kowalewski Daniel Johannes, Backert Linus, Nelde Annika, Kohlbacher Oliver, Weide Benjamin, Kanz Lothar, Salih Helmut Rainer, Rammensee Hans-Georg, Stevanović Stefan
a Department of Hematology and Oncology , University of Tübingen , Tübingen , Germany.
b Department of Immunology , Institute for Cell Biology, University of Tübingen , Tübingen , Germany.
Leuk Lymphoma. 2018 Aug;59(8):1949-1958. doi: 10.1080/10428194.2017.1403022. Epub 2018 Jan 3.
The course of chronic lymphocytic leukemia (CLL), inducing an immunosuppressed state that also affects T cells as central components of adaptive immunity, predisposes patients to develop second malignancies with skin cancer being the most common. Recently, we found that prevalence of memory T cells with specificity for CLL-associated antigens defined by mass spectrometry-based immunopeptidome analysis correlated with a significant survival benefit. Here, we analyzed our CLL patient cohort for second skin (pre)malignancies and found a significantly lower incidence of skin cancer in the patients showing immune responses to CLL-associated antigens. Surprisingly, CLL-associated antigen-specific immune responses did not associate with clinical characteristics including leukocyte, neutrophil, and thrombocyte count, hemoglobin, immunoglobulin levels, or CD8 and CD4 T-cell immune status. Our data indicate that the CLL-specific immune signature of a given patient, defined by antigen-specific T-cell responses, might represent an independent marker to identify CLL patients susceptible for the development of skin malignancies.
慢性淋巴细胞白血病（CLL）病程会引发免疫抑制状态，这种状态也会影响作为适应性免疫核心成分的T细胞，使患者易患第二原发性恶性肿瘤，其中皮肤癌最为常见。最近，我们发现，通过基于质谱的免疫肽组分析确定的对CLL相关抗原有特异性的记忆T细胞的患病率与显著的生存获益相关。在此，我们分析了我们的CLL患者队列中的第二原发性皮肤（癌前）恶性肿瘤情况，发现对CLL相关抗原有免疫反应的患者中皮肤癌的发病率显著较低。令人惊讶的是，CLL相关抗原特异性免疫反应与包括白细胞、中性粒细胞和血小板计数、血红蛋白、免疫球蛋白水平或CD8和CD4 T细胞免疫状态在内的临床特征无关。我们的数据表明，由抗原特异性T细胞反应定义的特定患者的CLL特异性免疫特征可能是识别易患皮肤恶性肿瘤的CLL患者的独立标志物。
