酶预处理加局部递送 HB-IGF-1 刺激整合性软骨修复。
Enzyme Pretreatment plus Locally Delivered HB-IGF-1 Stimulate Integrative Cartilage Repair .
机构信息
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
出版信息
Tissue Eng Part A. 2019 Sep;25(17-18):1191-1201. doi: 10.1089/ten.TEA.2019.0013. Epub 2019 Sep 3.
Abstract
A critical attribute for the long-term success of cartilage defect repair is the strong integration between the repair tissue and the surrounding native tissue. Current approaches utilized by physicians fail to achieve this attribute, leading to eventual relapse of the defect. This article demonstrates the concept of a simple, clinically viable approach for enhancing tissue integration via the combination of a safe, transient enzymatic treatment with a locally delivered, retained growth factor through an hydrogel/cartilage explant model.
摘要
软骨缺损修复长期成功的一个关键属性是修复组织与周围天然组织之间的牢固整合。目前医生采用的方法无法实现这一属性，导致缺陷最终复发。本文通过水凝胶/软骨外植体模型展示了一种简单、临床可行的方法，通过将安全、短暂的酶处理与局部递送的、保留的生长因子相结合来增强组织整合的概念。
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